Browsing Faculty of Arts and Sciences by Author "Flaxman, Hope A."

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    • The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron 

      Ichikawa, Saki; Flaxman, Hope A.; Xu, Wenqing; Vallavoju, Nandini; Lloyd, Hannah C.; Wang, Binyou; Shen, Dacheng; Pratt, Matthew R.; Woo, Christina (Springer Science and Business Media LLC, 2022-10-19)
      The E3 ligase substrate adaptor cereblon (CRBN) is a target of thalidomide and lenalidomide,1 which are therapeutic agents used in the treatment of hematopoietic malignancies2-4 and as ligands for targeted protein ...