Browsing Faculty of Arts and Sciences by Keyword "Chemical biology"

Now showing items 1-6 of 6

    • Biochemical and Functional Ramifications of SMARCE1 Loss in Clear Cell Meningioma and Coffin Siris Syndrome 

      St Pierre , Roodolph P (2021-09-07)
      Mutations in SMARCE1, which encodes the BAF57 subunit of the mammalian Switch/Sucrose Non-Fermentable (mSWI/SNF) ATP-dependent chromatin remodeling complex, have been identified in patients afflicted with clear cell ...

    • Chemoproteomic target-class drug discovery against the deubiquitinating enzymes 

      Chan, Wai Cheung (2022-03-17)
      Modern small molecule drug discovery is dominated, and subsequently limited by a paradigm of reversible non-covalent inhibitors. The deubiquitinating enzymes (DUBs) is a class of ~100 proteases that regulate normal and ...

    • From Probes to Therapeutics: Chemical Biology Studies of Anaplastic Lymphoma Kinase (ALK) and Cereblon 

      Powell, Chelsea Elizabeth (2020-01-22)
      Although there is still discussion surrounding the exact definition of the field, chemical biology is generally described as the development and deployment of a chemical toolbox to manipulate biological systems. The two ...

    • Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth 

      Stanley, Sarah A.; Barczak, Amy K.; Silvis, Melanie R.; Luo, Samantha S.; Sogi, Kimberly; Vokes, Martha; Bray, Mark-Anthony; Carpenter, Anne E.; Moore, Christopher B.; Siddiqi, Noman; Rubin, Eric J.; Hung, Deborah T. (Public Library of Science, 2014)
      Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. tuberculosis infection, and although bacteria are able to replicate intracellularly under certain conditions, ...

    • The Metabolite α-Ketoglutarate Extends Lifespan by Inhibiting ATP Synthase and TOR 

      Chin, Randall M.; Fu, Xudong; Pai, Melody Y.; Vergnes, Laurent; Hwang, Heejun; Deng, Gang; Diep, Simon; Lomenick, Brett; Meli, Vijaykumar S.; Monsalve, Gabriela C.; Hu, Eileen; Whelan, Stephen A.; Wang, Jennifer X; Jung, Gwanghyun; Solis, Gregory M.; Fazlollahi, Farbod; Kaweeteerawat, Chitrada; Quach, Austin; Nili, Mahta; Krall, Abby S.; Godwin, Hilary A.; Chang, Helena R.; Faull, Kym F.; Guo, Feng; Jiang, Meisheng; Trauger, Sunia A; Saghatelian, Alan; Braas, Daniel; Christofk, Heather R.; Clarke, Catherine F.; Teitell, Michael A.; Petrascheck, Michael; Reue, Karen; Jung, Michael E.; Frand, Alison R.; Huang, Jing (Nature Publishing Group, 2014)
      Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary restriction consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms1, 2. Similar conditions ...

    • A system for the continuous directed evolution of biomolecules 

      Esvelt, Kevin Michael; Carlson, Jacob C.; Liu, David Ruchien (Nature Publishing Group, 2011)
      Laboratory evolution has generated many biomolecules with desired properties, but a single round of mutation, gene expression, screening or selection, and replication typically requires days or longer with frequent human ...