Browsing Faculty of Arts and Sciences by Keyword "DNA repair"
Now showing items 1-5 of 5
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Extreme Resistance of Bdelloid Rotifers to Ionizing Radiation
(National Academy of Sciences of the United States of America, 2008)Rotifers of class Bdelloidea are common invertebrate animals with highly unusual characteristics, including apparently obligate asexuality, the ability to resume reproduction after desiccation at any life stage, and a ... -
Killing the Umpire: Cooperative Defects in Mitotic Checkpoint and BRCA2 Genes on the Road to Transformation
(BioMed Central, 1999)Recent findings from mouse models of BRCA2 genetic lesions have provided intriguing insights and important questions concerning modes of tumor development in familial breast and ovarian cancers. Fibroblasts from mice ... -
Quantitative Analysis of DNA Repair and p53 in Individual Human Cells
(2013-03-18)The goal of my research was to obtain a quantitative understanding of the mechanisms of DNA double-strand break (DSB) repair, and the activation of the tumor suppressor p53 in response to DSBs in human cells. In Chapter ... -
Regulation of the Fanconi Anemia Pathway by Deubiquitination
(2013-02-08)Fanconi anemia (FA) is a rare genetic disease characterized by bone marrow failure and cancer predisposition. Cell lines derived from FA patient exhibit chromosomal instability and sensitivity to DNA interstand crosslinkers ... -
The Ubiquitin Ligase \(CRL4^{Cdt2}\) Targets Thymine DNA Glycosylase for Destruction during DNA Replication and Repair
(2013-09-30)The E3 ubiquitin ligase \(CRL4^{Cdt2}\) targets proteins for destruction during DNA replication and following DNA damage (Havens and Walter, 2011). Its substrates contain "PIP degrons" that mediate substrate binding to the ...