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Mechanisms of Stem Cell Maintenance and Cell Differentiation in the Intestinal Epithelium
(2015-01-23)
Constant regeneration of the intestinal epithelium, a dynamic tissue with vital digestive and barrier functions, depends on proliferation of resident stem cells and their differentiation into mature cell types. This ...
The Mechanistic Basis of Dynein Microtubule Binding and Its Regulation
(2015-01-22)
Eukaryotic cells use a diverse toolbox of cytoskeletal motors to transport and position cellular materials in space and time. Two microtubule-based motors—kinesin and dynein—transport organelles, RNA and protein cargos ...
Spatial Organizing Principles of Cytokinesis Signaling
(2015-09-23)
Cytokinesis is the final step of cell division, in which the cytoplasm of one cell is physically divided into two. Animal cells integrate multiple positional cues from the mitotic spindle to decide where to position their ...
Investigating the Role of Sox2 in Stomach Tissue Homeostasis and Cancer.
(2015-05-16)
The transcription factor Sox2 is essential for the establishment and maintenance of multiple stem cell populations and its coding region is amplified in certain carcinomas. However, Sox2’s role in stomach homeostasis and ...
The Hippo Pathway Effector YAP Regulates Cytokinesis
(2015-05-17)
Yes-associated protein (YAP) is a co-transcription factor that acts downstream of the evolutionarily conserved Hippo pathway. Canonically, this pathway regulates tissue growth in flies and mammals, by controlling the nuclear ...
In Vivo and in Vitro Characterization of the Tumor Suppressive Function of INPP4B
(2015-05-16)
The phosphatases PTEN and INPP4B are frequently deregulated in human cancer and have been proposed to act as tumor suppressor genes by coordinately antagonizing PI3K/AKT signaling. While the function of PTEN has been ...
The Discovery and Characterization of the lncRNA Firre
(2015-05-08)
RNAs, including long noncoding RNAs (lncRNA), are known to be abundant and important structural components of the nuclear infrastructure. Yet, the identities, functional roles, and localization dynamics of lncRNAs that ...
Molecular Mechanism of Secretory Protein Translocation by the SecA ATPase
(2015-05-06)
In bacteria, most secretory proteins are translocated across the plasma membrane by the interplay of the SecA ATPase and the SecY channel. How SecA moves a broad range of polypeptide substrates is only poorly understood. ...
Control of HIV-1C Replication Both in Vivo and in Vitro
(2015-05-18)
In this study, we established an HIV latency model using pluripotent stem cells in vitro. We found that a HIV accessory protein nef is responsible for full-length HIV silencing in human pluripotent stem cells. This effect ...
VEGF-Dependent Mechanisms Controlling Osteoblast Differentiation and Bone Formation During Bone Repair
(2015-05-05)
Osteoblast-derived vascular endothelial growth factor (VEGF) is important for bone development and postnatal bone homeostasis. Several studies have demonstrated that VEGF affects bone repair and regeneration; however, the ...