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Regulation of Behavioral Arousal and Quiescence in C. elegans
(2016-05-13)
Animals switch between periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. C. elegans exhibit periods of behavioral quiescence during larval molts (termed lethargus) ...
Organization of Postsynaptic Assembly by Filamin at the Drosophila Neuromuscular Junction
(2016-05-16)
Proper postsynaptic assembly is a fundamental requirement for circuit function, yet our understanding of its molecular mechanism is incomplete. The Drosophila neuromuscular junction is a powerful system for genetically ...
Strategies for Studying Chromatin Regulation and Organization
(2016-04-22)
The epigenetic regulation of gene transcription underlies the diversity between species and within organisms. Novel implementation of existing methods and the development of original technologies continue to contribute ...
Identification of New Regulators of Tendon Development Using the Zebrafish Model
(2016-05-12)
Tendons transmit force from muscle to bone, enabling movement; ligaments connect bone to bone, maintaining stability. Despite their importance, tendon and ligament development is relatively uncharacterized. In this ...
Mutations in the Charged Domain of CBX2 Disrupt PRC1 Function in Vivo
(2016-05-06)
Epigenetics inheritance is a phenomenon where a cell state is inherited across cellular divisions. It is important for maintaining differentiated cells types, and thus is fundamental to the development of multicellular ...
Genetic Methods and Studies of Human Growth and Development Across the Allelic Spectrum
(2016-05-09)
Genetics is an incredibly powerful tool for interrogating human biology, as it allows us to identify genes influencing biological processes and diseases in a hypothesis-free manner and in the context of the human body. The ...
Modeling Rare Protein-Coding Variation to Identify Mutation-Intolerant Genes With Application to Disease
(2016-05-06)
Sequencing exomes—the 1% of the genome that codes for proteins—has increased the rate at which the genetic basis of a patient’s disease is determined. Unfortunately, when a patient does not carry a well-established pathogenic ...
It Takes Brains: Germline and Somatic Mutations in Neurodevelopmental Disorders
(2016-05-05)
The human brain can be affected by many diseases during its development, and human genetics studies can illuminate the genetic etiology of these diseases, which is critical for understanding disease pathophysiology, improving ...
Molecular Patterns and Signatures of Longevity
(2016-05-02)
Since their divergence from a common ancestor some 200 million years ago, mammals have undergone significant diversification in physiology, morphology, habitat, size, and longevity. The maximum lifespan of mammalian species ...
Envelope biogenesis and spore formation in Bacillus subtilis
(2016-05-02)
The bacterial cell wall exoskeleton (or peptidoglycan) protects cells from osmotic lysis, specifies their shape, and its biosynthetic pathway is a widely-exploited antibiotic target. My thesis research focused on defining ...