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Optical control of mammalian endogenous transcription and epigenetic states
(2014-06-06)
The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates ...
A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development
(Elsevier BV, 2017-01)
During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal analyses to reveal lineage trees and molecular ...