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Statistical Methods for Analyzing DNA Methylation Data and Subpopulation Analysis of Continuous, Binary and Count Data for Clinical Trials
(2015-01-13)
DNA methylation may represent an important contributor to the missing heritability described in complex trait genetics. However, technology to measure DNA methylation has
outpaced statistical methods for analysis. Novel ...
Cell States and Cell Fate: Statistical and Computational Models in (Epi)Genomics
(2015-01-14)
This dissertation develops and applies several statistical and computational methods to the analysis of Next Generation Sequencing (NGS) data in order to gain a better understanding of our biology. In the rest of the chapter ...
Evolutionary Dynamics of a Multiple-Ploidy System in Arabidopsis Arenosa
(2015-05-18)
Whole-genome duplication (WGD), which leads to polyploidy, has been implicated in speciation and biological novelty. In plants, many species have experienced historical bouts of WGD or exhibit extant ploidy variation, which ...
Towards a Systematic Approach for Characterizing Regulatory Variation
(2015-11-03)
A growing body of evidence suggests that genetic variants that alter gene expression are responsible for many phenotypic differences across individuals, particularly for the risk of developing common diseases. However, the ...
The MiR-130/301 Family Controls Cellular Survival in Pulmonary Hypertension
(2015-06-26)
Pulmonary hypertension (PH) is a deadly vascular disease characterized by multiple disparate molecular pathways controlling vasoconstriction and hyperproliferation throughout the pulmonary vasculature. Importantly, the ...