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α-Synuclein Induces Mitochondrial Dysfunction Through Spectrin and the Actin Cytoskeleton
(2018-09-16)
Abnormal accumulation of the cytoplasmic protein α-synuclein in vulnerable neurons and glial is a pathological hallmark of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, collectively termed ...
Dendrite Patterning as a Model for Self-Organizing Systems
(2018-01-05)
Biological systems self-organize into complex well-ordered structures and can evolve new patterns when perturbed. To identify principles underlying self-organization, I turned to the model organism C. elegans for its ...
Mechanisms of Scale Invariance in Embryonic Patterning Systems
(2018-05-10)
Embryos pattern themselves with remarkable consistency and readily adjust their patterning programs to drastic changes in embryo size. This robustness of pattern formation, termed scale invariance, requires cells to determine ...