Search
Now showing items 1-2 of 2
Deletion of Prepl Causes Growth Impairment and Hypotonia in Mice
(Public Library of Science, 2014)
Genetic studies of rare diseases can identify genes of unknown function that strongly impact human physiology. Prolyl endopeptidase-like (PREPL) is an uncharacterized member of the prolyl peptidase family that was discovered ...
The Metabolite α-Ketoglutarate Extends Lifespan by Inhibiting ATP Synthase and TOR
(Nature Publishing Group, 2014)
Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary restriction consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms1, 2. Similar conditions ...