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Now showing items 31-36 of 36
Cooking shapes the structure and function of the gut microbiome
(Springer Science and Business Media LLC, 2019-09-30)
Diet is a critical determinant of variation in gut microbial structure and function, outweighing even host genetics. Numerous microbiome studies have compared diets with divergent ingredients, but the everyday practice of ...
A genomics love story: Tying the knot between micro- and macroevolution in the Mycobacterium tuberculosis complex
(2021-08-24)
Tuberculosis (TB) is a leading cause of death globally. Understanding the population dynamics and evolution of TB’s causative agent Mycobacterium tuberculosis complex (MTBC) over short time-scales in-host (micro-evolution) ...
Applications of recombineering and recoded genome construction.
(2022-06-06)
Genome engineering offers the opportunity to bypass natural selection to generate novel organisms. Although multiple types of genome engineering are currently possible, work described in this dissertation occurred in the ...
Genetics of Antibiotic Synergy in Mycobacterium tuberculosis
(2022-09-09)
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb), which has been around for millennia and continues to affect millions of people every year. Successful TB treatment requires ...
Single-molecule imaging reveals that Z-ring condensation is essential for cell division in Bacillus subtilis
(Springer Science and Business Media LLC, 2021-03-18)
Although many components of the cell division machinery in bacteria have been identified, the mechanisms by which they work together to divide the cell remain poorly understood. Key among these components is the tubulin ...
Population genomics of the emerging pathogen Mycobacterium abscessus
(2023-06-01)
Mycobacterium abscessus is an emerging pathogen that is increasingly responsible for pulmonary-associated morbidity and mortality, most commonly in patients with underlying lung disease. Previous work has revealed the ...