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Direct Characterization of Cis-Regulatory Elements and Functional Dissection of Complex Genetic Associations Using HCR–FlowFISH
(Springer Science and Business Media LLC, 2021-07-29)
Abstract: Effective interpretation of genome function and genetic variation requires a shift from epigenetic mapping of cis-regulatory elements (CREs) to characterization of endogenous function. We developed HCR-FlowFISH, ...
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells
(Springer Science and Business Media LLC, 2022-05)
<jats:p>Genome-wide association studies have uncovered hundreds of autoimmune disease-associated loci; however, the causal genetic variant(s) within each locus are mostly unknown. Here, we perform high-throughput allele-specific ...