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Motor Memories for Expectation and Uncertainty in the Environment
(2015-04-30)
The motor system endows us with the ability to control movement – an ability that provides us, almost exclusively, with the means through which we interact with our environment. To accomplish this, the motor system ...
Analysis of Voluntary Behavior to Interrogate Neural Function
(2016-02-11)
Mice and rats are critical to our understanding of human biology. They share most of our genome, are susceptible to most of the same diseases and usually benefit from clinical therapeutics, if only at very high doses. ...
Integrated Nanoscale Tools for Interrogating Living Cells
(2015-05-13)
The development of next-generation, nanoscale technologies that interface biological systems will pave the way towards new understanding of such complex systems. Nanowires – one-dimensional nanoscale structures – have shown ...
The Stability of Motor Memories
(2018-05-08)
The ease and grace of animal movements belie the incredible challenge of controlling those movements, as the motor system does so capably. To maintain this fine control, the motor system needs to adapt to changes in the ...
Engineering in Vitro Human Induced Pluripotent Stem Cell-Derived Brain Cell Models for Alzheimer’s Disease and Down Syndrome
(2018-09-25)
In disease biology, animal models are widely used. By offering insights on disease etiology, they allow us to systematically examine the complexity of a disease and its mechanisms. However, over the last decade, failures ...