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The Effect of Development and Ecology on the Evolution of Ovary Size in Drosophila
(2015-05-20)
How the size of an organ is established and altered during evolution is poorly understood. The ovary of fruit flies of the genus Drosophila serves as an interesting model for understanding organ size evolution, as the ...
The Wnt5a-Ror Signaling Pathway in the Morphogenesis of the Embryo
(2015-07-13)
Embryonic development is orchestrated by relatively few conserved core developmental signaling pathways that are used reiteratively to grow, specify and shape all tissues in the body into their final functional forms. The ...
Experimental and Computational Tools to Study P53 Dynamics at the Single-Cell Level
(2015-09-21)
One of the most commonly mutated genes found in cancer is the tumor suppressor p53. p53 is a transcription factor capable of inducing cell-cycle arrest, apoptosis, senescence, and other cellular processes thought to halt ...
The Molecular Determinants of Cranial Skeletal Development and Evolution
(2015-10-01)
The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...
Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
Regulation of Yolk Catabolism in Early Embryogenesis
(2015-08-19)
Yolk provides an important source of nutrients during the early development of oviparous (non-platental) organisms. In addition to phosphate and lipids, it is com- posed mainly of vitellogenin proteins packed into ...
Genome-Wide RNAi Screens for Novel Regulators of Acute Myeloid Leukemia
(2015-01-15)
Acute myeloid leukemia (AML) is a heterogeneous disease with complex molecular mechanisms. Recent advent of genomic technologies, such as copy number profiling, whole genome sequencing, and gene expression profiling has ...
PI3K regulatory subunit p85alpha plays a tumor suppressive role in the transformation of mammary epithelial cells
(2015-01-15)
Hyperactivation of the phosphatidylinositol 3-kinase (PI3K) pathway is one of the most common events in human cancers. Class IA PI3Ks are heterodimers of a p110 catalytic and a p85 regulatory subunit that coordinate the ...
Oligopaints: Highly Programmable Oligonucleotide Probes for Visualizing Genomes in Situ
(2015-01-29)
Fluorescence in situ hybridization (FISH) is a powerful assay that can visualize the position of DNA and RNA molecules in individual cells. Here, I describe the development of a method that utilizes complex oligonucleotide ...
Bioinformatic and molecular study of the regulation of SIRT3 expression
(2015-01-29)
Calorie restriction (CR) is a dietary intervention that extends lifespan, delays the onset of age-related diseases, and induces a wide-ranging metabolic adaptation in multiple model organisms. One of its primary effectors ...