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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(2016-05-14)
Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ...
Investigation of the Mechanism That Powers DNA Translocation During Bacterial Natural Transformation
(2016-07-26)
If deoxyribonucleic acids are the building blocks of life, perhaps the proteins that move, shape, and assemble nucleic acids should be called architects. These proteins come in every size and shape and have vastly different ...
A genetic dissection of the interactions between the CbtA toxin of Escherichia coli and the bacterial cytoskeleton
(2016-09-15)
Prokaryotic chromosomal toxin-antitoxin (TA) systems, consisting of a stable toxin and a labile, cotranscribed antitoxin, have been shown to target a number of essential processes in bacteria. The Escherichia coli genome ...
Clp-Mediated Regulation of the Mycobacterial Cell Cycle
(2017-04-12)
Tuberculosis is currently the most deadly infectious disease worldwide. Given the high rates of treatment failure, new antibiotics are desperately needed. Antibacterial drugs typically target DNA replication, cell growth, ...
The Role of MreB in Producing Rod-Shaped Bacterial Cells
(2017-09-08)
MreB, an actin homolog, is known to form short, membrane-associated filaments that move circumferentially in rod-shaped bacteria, in association with cell wall-synthesizing enzymes. Despite being essential for rod shape, ...
Flagellar Biosynthesis in E.coli Is Regulated by a Cascade of Stochastic Pulses
(2017-01-20)
Genetically identical populations of bacteria can exhibit significant phenotypic heterogeneity even in the absence of environmental variations. In bacteria such as Bacillus and Salmonella, flagellar motility has been found ...
Free Actin and Effects on Lung Macrophage Bacterial Defenses
(2017-02-10)
Actin release into the circulation and extracellular space, with subsequent removal by the actin scavenging protein plasma gelsolin (pGSN), has long been reported in injury and infection.
Our laboratory’s recent finding ...