Browsing HSDM Theses and Dissertations by Title
Now showing items 13-32 of 49
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Deletion of the Parathyroid Hormone Receptor in Marrow Adipose Lineage Precursors (MALPs) Prevents Their Negative Regulation of Skeletal Homeostasis
(2021-05-19)Background and objectives: Parathyroid hormone (PTH) is essential for skeletal homeostasis and PTH[1-34] (teriparatide) is used to treat severe osteoporosis, medication-related osteonecrosis of the jaws, and enhance implant ... -
Dental Care Utilization and Oral Diseases Among US Older Adults with Depressive Symptoms and Difficulty with Physical Functioning
(2024-04-30)Objectives: To investigate the oral health status and the prevalence of dental care utilization among older adults experiencing depressive symptoms and difficulty with physical functioning. Methods: This study was a ... -
Determination of Attitudes and Knowledge about Patient Perceptions of Expanded Roles and Responsibilities for Dentists as "Oral Physicians"
The overall objective of this study was to determine knowledge and attitudes of dentists and patients about dentists’ expanding their roles in preventive primary health care as oral physicians. There are hundreds of genetic ... -
Development of Novel Anti-DC-STAMP Monoclonal Antibody Targeting Osteolytic Periodontal Lesion
(2016-08-16)Background: Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion. This conclusion is supported by evidence showing that osteoclast cell fusion is diminished, ... -
Effect of endodontic treatment on local inflammatory biomarkers in teeth with apical periodontitis
(2024-04-30)Abstract Effect of endodontic treatment on local inflammatory biomarkers in teeth with apical periodontitis Sam Yun DDS, Joshua Hong DMD MMSc, Pallavi Suhag DDS MMSc, Summer Tan, Ozge Erdogan DDS DMSc, Jennifer Gibbs ... -
Efficacy of a Smart Toothbrush on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Chronic Periodontitis. A Prospective Randomized Controlled Clinical trial.
(2024-04-30)Background: Periodontitis is the 11th most prevalent chronic disease globally, with a disease burden of approximately 1.1 billion people. Similarly, type 2 diabetes mellitus (T2DM) is a global health concern affecting 537 ... -
Electrokinetic Flow Assisted Dentin Disinfection
(2021-07-19)Background: The bacterial persistence within the root canals and dentinal tubules in infected and necrotic pulp poses a serious health risk, with reinfection of the endodontically treated tooth being one of the main problems ... -
Evaluation of αLphav Integrin Role in Mouse Model Induced Periapical Periodontitis
(2016-08-16)Abstract: Background: alphav (av) integrin is the most common integrin alpha subunit, it is expressed in different cells and involved in many cellular process including adhesion, migration, survival and growth factor ... -
Experimental Evaluation of Discoid Domain Receptor 2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs
(2015-07-02)Abstract: Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its ... -
Expression of Free Fatty Acids and their Receptors on Oral Neutrophils in Oral Lichen Planus
(2024-04-30)Objectives: The aim of this project is to assess expression of specialized pro-resolving lipid mediators (SPMs) and inflammation resolution receptors on oral neutrophils (oPMNs) in oral lichen planus (OLP) compared to ... -
Halofuginone Prevents the Progression of Osteoarthritis
(2015-07-02)Background: Halofuginone (HF) is a natural product that has been shown to have therapeutic benefits in a variety of pathologic conditions, from cancer to autoimmune diseases. These beneficial effects are mainly through ... -
Highly Spatial Mapping of Oral Microbial Communities in Peri-implant Health and Disease
(2024-04-30)Background: Peri-implant mucositis and peri-implantitis are pathological conditions occurring in tissues around dental implants. Both diseases are characterized by inflammation in the peri-implant connective tissue, but ... -
Immune Reconstitution of B Cells Following Allogeneic Hematopoietic Cell Transplantation
(2015-07-02)Objectives: Graft versus host disease (GVHD), infections and disease relapse continue to be major complications of allogeneic hematopoietic cell transplantation (HCT). B cell abnormalities have been associated with these ... -
Immunomodulation of Macrophages in Periapical Wound Healing
(2016-08-16)Background: A periapical lesion is an infection-induced inflammation around the apex of the tooth caused by bacterial invasion and ultimately results in the destruction of bone in the area. To date, the relationship between ... -
Impact of Resolvin E1 on Experimental Periodontitis and Periodontal Biofilm
(2015-07-02)Objective: The goal of this project was to determine the impact of local inflammation on changes in the subgingival biofilm composition in ligature-induced periodontitis in rats using the specialized pro-resolving mediator ... -
Individualizing Aligner Change Schedule: A Single-Blind, Randomized Controlled Trial
(2024-04-30)Introduction: Presently, patients’ aligner change frequency and wear time are primarily determined by the clinician’s judgment rather than by literature comparing distinct protocols. The aims of this study are to evaluate ... -
Longitudinal Clinical Outcomes and Cost- Effectiveness Evaluation of a Comprehensive School- Based Dental Prevention Program – ForsythKids
(2016-08-16)We aimed to evaluate longitudinal clinical outcomes and cost-effectiveness of a comprehensive school-based caries prevention program, ForsythKids. In collaboration with the Massachusetts Department of Health, we solicited ... -
Macrophage Function in Processing of Excess Dietary Fat
(2024-04-29)Background: Chronic low-grade metabolic inflammation is one of the hallmarks of metabolic diseases. The risk of periodontitis is approximately threefold higher in diabetic individuals. To examine this relationship, we used ... -
Neuronal-immune Changes During Pulpitis
(2024-04-30)Introduction: Dental pulp tissue is densely innervated and it has unique immunological characteristics. Upon injury such as deep caries, exposing the pulp, a strong neuronal and immune response occurs which modulates pain ... -
The Possible Roles of CD73 and Adenosine in the Osteoimmunological Bone Resorption of Periradicular Periodontitis
(2016-08-16)Introduction: Periradicular periodontitis is an inflammatory disease caused by perpetual microbial infection in the root canal system which, if left untreated, results in the destruction of tooth supporting tissues. Tenacious ...