Browsing HSDM Theses and Dissertations by Title
Now showing items 1-20 of 58
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A Method to Trace Porphyromonas gingivalis Within Periodontal Ligament in 3D
(2021-05-07)Background and Objective: Periodontitis is an inflammatory disease caused by bacterial dysbiosis that leads to tooth support loss and eventually, loss of tooth. There have been studies using micro-CT, histology, and electron ... -
A Novel Injectable Hydrogel Incorporating Lipoxin for Treatment of Inflammation-mediated Bone Resorption
(2021-07-19)Increased inflammation can disturb bone homeostasis leading to increased osteoclastogenesis and bone resorption. Studies have demonstrated that specialized pro-resolving lipid mediators such as lipoxins, can counteract ... -
A Protocol to Discover Endodontic Diagnostic Biomarkers After Traumatic Dental Injuries in Immature Teeth
(2024-04-30)Introduction: Having an accurate diagnosis following a traumatic dental injury (TDI) is fundamental for appropriate, conservative treatment that will allow minimal destruction and maximum regain of function. However, ... -
Abaloparatide to Treat Alveolar Bone Loss for Dental Implant Reconstruction
(2024-05-20)Systemic administration of ABL significantly reduces the risk of fragility fractures in the femur, hip, and vertebrae, but no data exists on the likely positive effects that could be exerted on alveolar bone of the jaws. ... -
An Investigation of Posttreatment Facial Harmony in Accordance with Steiner Estimates
(2024-05-03)Contemporary orthodontic practices slowly adopt modern technologies, new treatment tools, and soft-tissue-based diagnostic approaches. Classic diagnostic tools, especially those concerning the cephalometric positioning of ... -
Analyzing the Accuracy of a Cross-Mounting Technique Utilizing Digital Occlusal Registrations
(2024-04-30)This study aimed to compare the accuracy of a partially digital cross-mounting workflow utilizing direct scans of interocclusal records to a conventional workflow through the analysis of deviations in sequentially cross-mounted ... -
Assessing the Neurotoxicity of Endodontic Sealers
(2021-08-12)Many times the relationship between dental materials and clinical outcomes is poorly understood because so little is known about the biocompatibility of materials and the biological pathways they may affect. In endodontics, ... -
Assessing wellness and burnout among dental faculty in the US during COVID-19
(2024-04-29)Background: Through the progression of the COVID-19 global health crisis, dental education was under transformation. The work environment for dental faculty was characterized by new educational and administrative challenges ... -
Attenuation of the Progression of Articular Cartilage Degeneration by Inhibition of Tgf-β1 Signaling in a Mouse Model of Osteoarthritis
(2015-07-02)Background The goal of this study is to understand role of transforming growth factor beta 1 (TGF-β1) in development of osteoarthritis (OA). Results from studies indicate that the genetic inactivation of Smad-3, or the ... -
Biologic Significance of 5-Hydroxymethylcytosine Expression in Oral Mucosal Epithelial Dysplasia and Oral Squamous Cell Carcinoma
(2016-03-03)Current modeling postulates that the development of cancer is driven by the accumulation of genetic mutations and epigenetic modifications, resulting in a clonal population of cells with deregulated growth characteristics. ... -
Cellular Response to Expansion and Compression Forces in Mouse Midpalatal Suture and Surrounding Structures
(2016-08-16)Objectives – To investigate the anatomy of the mouse palate, the midpalatal suture, and the cellular characteristics in the sutures before and immediately after midpalatal suture expansion, and as well as, to study the ... -
Comparative Analysis of Sharpening Devices on Periodontal Hand Instruments and their Impact on Root Surface Roughness: An In Vitro study
(2024-05-20)The role of bacterial plaque and its role as the primary etiology for periodontal disease is well established. The treatment of periodontitis and maintenance of periodontal health is dependent on the elimination of plaque, ... -
A Comparison of Zirconia CAD/CAM to Conventionally Fabricated Single Implant Restorations in the Esthetic Zone
(2015-07-02)Objective: This project aimed to determine whether single tooth implant restorations fabricated with CAD/CAM zirconia abutments/porcelain fused to zirconia crowns reveal different biological and esthetic outcomes compared ... -
A Comprehensive Assessment of Soft Tissue Esthetics
(2015-07-02)This thesis investigated the efficacy of two techniques, digital spectrophotometry and narrow-band endoscopy, in observing and describing gingival tissue in a patient population. The efficacy of existing gingival restorative ... -
Comprehensive Optical Assessment of Peri-Implant Mucosa
(2015-07-02)Esthetic outcomes with implants begin with proper implant placement, but the predictability of the peri-implant esthetic outcome is also affected by patient’s pre-existing or reconstructed local tissue. An unpleasant optical ... -
Deletion of the Parathyroid Hormone Receptor in Marrow Adipose Lineage Precursors (MALPs) Prevents Their Negative Regulation of Skeletal Homeostasis
(2021-05-19)Background and objectives: Parathyroid hormone (PTH) is essential for skeletal homeostasis and PTH[1-34] (teriparatide) is used to treat severe osteoporosis, medication-related osteonecrosis of the jaws, and enhance implant ... -
Dental Care Utilization and Oral Diseases Among US Older Adults with Depressive Symptoms and Difficulty with Physical Functioning
(2024-04-30)Objectives: To investigate the oral health status and the prevalence of dental care utilization among older adults experiencing depressive symptoms and difficulty with physical functioning. Methods: This study was a ... -
Determination of Attitudes and Knowledge about Patient Perceptions of Expanded Roles and Responsibilities for Dentists as "Oral Physicians"
The overall objective of this study was to determine knowledge and attitudes of dentists and patients about dentists’ expanding their roles in preventive primary health care as oral physicians. There are hundreds of genetic ... -
Development of Novel Anti-DC-STAMP Monoclonal Antibody Targeting Osteolytic Periodontal Lesion
(2016-08-16)Background: Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key role in the induction of osteoclast (OC) cell fusion. This conclusion is supported by evidence showing that osteoclast cell fusion is diminished, ... -
Echo Doppler Ultrasonographic Characterization of Healthy and Diseased Implant Sites
(2024-05-03)The study of peri-implant diseases is constantly evolving, from the best practices for detecting mucositis to treating mucositis to return the patient to peri-implant health and the interventions that can be used to treat ...