Browsing Harvard Medical School by Author "Li, Jianneng"

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    • Redirecting abiraterone metabolism to fine tune prostate cancer anti-androgen therapy 

      Li, Zhenfei; Alyamani, Mohammad; Li, Jianneng; Rogacki, Kevin; Abazeed, Mohamed; Upadhyay, Sunil K.; Balk, Steven P.; Taplin, Mary-Ellen; Auchus, Richard J.; Sharifi, Nima (2016)
      Abiraterone blocks androgen synthesis and prolongs survival in castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis1,2. Abiraterone is metabolized in patients to D4A, which has ...