Browsing Harvard Medical School by Author "Li, Jia"
Now showing items 1-4 of 4
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A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model
Li, Jia; Geisbush, Tom R.; Arnold, William D.; Rosen, Glenn D.; Zaworski, Phillip G.; Rutkove, Seward B. (Public Library of Science, 2014)Objectives: There is a need for better, noninvasive quantitative biomarkers for assessing the rate of progression and possible response to therapy in spinal muscular atrophy (SMA). In this study, we compared three ... -
Electrophysiologic Biomarkers for Assessing Disease Progression and the Effect of Riluzole in SOD1 G93A ALS Mice
Li, Jia; Sung, Minhee; Rutkove, Seward B. (Public Library of Science, 2013)Objective: To compare electrical impedance myography (EIM) 50 kHz phase to weight, motor score, paw grip endurance (PGE), CMAP amplitude, and MUNE for the identification of disease progression and the effect of riluzole ... -
Evaluation of Electrical Impedance as a Biomarker of Myostatin Inhibition in Wild Type and Muscular Dystrophy Mice
Sanchez, Benjamin; Li, Jia; Yim, Sung; Pacheck, Adam; Widrick, Jeffrey J.; Rutkove, Seward B. (Public Library of Science, 2015)Objectives: Non-invasive and effort independent biomarkers are needed to better assess the effects of drug therapy on healthy muscle and that affected by muscular dystrophy (mdx). Here we evaluated the use of multi-frequency ... -
A Technique for Performing Electrical Impedance Myography in the Mouse Hind Limb: Data in Normal and ALS SOD1 G93A Animals
Li, Jia; Staats, Wayne L.; Spieker, Andrew; Sung, Minhee; Rutkove, Seward Brian (Public Library of Science, 2012)Objective: To test a method for performing electrical impedance myography (EIM) in the mouse hind limb for the assessment of disease status in neuromuscular disease models. Methods: An impedance measuring device consisting ...