Browsing Harvard Medical School by Author "Medyouf, Hind"

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    • High-Level IGF1R Expression is Required for Leukemia-Initiating Cell Activity in T-ALL and is Supported by Notch Signaling 

      Medyouf, Hind; Gusscott, Samuel; Wai, Carol; Nemirovsky, Oksana; Trumpp, Andreas; Pflumio, Francoise; Carboni, Joan; Gottardis, Marco; Pollak, Michael; Holzenberger, Martin; Weng, Andrew P.; Wang, Hongfang; Tseng, Jen-Chieh; Kung, Andrew Li-Jen; Aster, Jon Christopher (Rockefeller University Press, 2011)
      T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer of immature T cells that often shows aberrant activation of Notch1 and PI3K–Akt pathways. Although mutations that activate PI3K–Akt signaling have previously ...