Browsing Harvard Medical School by Author "Rashidi, Maryam"

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    • RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL 

      Lawlor, Kate E.; Khan, Nufail; Mildenhall, Alison; Gerlic, Motti; Croker, Ben A.; D’Cruz, Akshay A.; Hall, Cathrine; Kaur Spall, Sukhdeep; Anderton, Holly; Masters, Seth L.; Rashidi, Maryam; Wicks, Ian P.; Alexander, Warren S.; Mitsuuchi, Yasuhiro; Benetatos, Christopher A.; Condon, Stephen M.; Wong, W. Wei-Lynn; Silke, John; Vaux, David L.; Vince, James E. (Nature Pub. Group, 2015)
      RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might drive inflammation in a manner independent ...