Browsing Harvard Medical School by Author "Li, Kaiyi"
Now showing items 1-2 of 2
-
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly
Lin, Shiaw-Yih; Rai, Rekha; Li, Kaiyi; Xu, Zhi-Xiang; Elledge, Stephen J. (National Academy of Sciences, 2005)BRIT1 [BRCT-repeat inhibitor of hTERT expression], a repressor of human telomerase function, is implicated in cellular immortalization. Here, we find that BRIT1 acts as a regulator of both the intra-S and G(2)/M checkpoints. ... -
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
Lin, Shiaw-Yih; Li, Kaiyi; Stewart, Grant S.; Elledge, Stephen J. (National Academy of Sciences, 2004)Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus, phosphorylated Claspin binds to xChk1 and regulates xChk1 activation in response to replication stress. ...