Browsing Harvard Medical School by Author "Li, Kai"

Now showing items 1-3 of 3

    • Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice 

      Zhou, Jingming; Chen, Qian; Lanske, Beate; Fleming, Braden C; Terek, Richard; Wei, Xiaochun; Zhang, Ge; Wang, Shaowei; Li, Kai; Wei, Lei (BioMed Central, 2014)
      Introduction: Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, ...

    • Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies 

      Wang, Gang; McCain, Megan L.; Yang, Luhan; He, Aibin; Pasqualini, Francesco Silvio; Agarwal, Ashutosh; Yuan, Hongyan; Jiang, Dawei; Zhang, Donghui; Zangi, Lior; Geva, Judith; Roberts, Amy E.; Ma, Qing; Ding, Jian; Chen, Jinghai; Wang, Da-zhi; Li, Kai; Wang, Jiwu; Wanders, Ronald J. A.; Kulik, Wim; Vaz, Frédéric M.; Laflamme, Michael A.; Murry, Charles E.; Chien, Kenneth R.; Kelley, Richard I.; Church, George M.; Parker, Kevin Kit; Pu, William T. (2014)
      Studying monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial roles in cardiac development and disease. Here, we combine patient-derived and genetically engineered iPSCs with tissue engineering ...

    • Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System 

      Li, Kai; Wang, Gang; Andersen, Troels; Zhou, Pingzhu; Pu, William T. (Public Library of Science, 2014)
      Designer nucleases such as TALENS and Cas9 have opened new opportunities to scarlessly edit the mammalian genome. Here we explored several parameters that influence Cas9-mediated scarless genome editing efficiency in murine ...