Browsing Harvard Medical School by Author "Li, Jun"

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    • Carboxamide SIRT1 Inhibitors Block DBC1 Binding via an Acetylation-Independent Mechanism 

      Loh, Christine; Gomes, Ana P; Li, Jun; Disch, Jeremy S; Ellis, James L; Vlasuk, George P; Sinclair, David; Hubbard, Basil; Gomes, Ana Catarina; Doyle, Taylor; Armor, Sean (Landes Bioscience, 2013)
      SIRT1 is an NAD+-dependent deacetylase that counteracts multiple disease states associated with aging and may underlie some of the health benefits of calorie restriction. Understanding how SIRT1 is regulated in vivo could ...