Browsing Harvard Medical School by Author "Franklin, Andrew"
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Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions
Zhang, Tingting; Franklin, Andrew; Boboila, Cristian; McQuay, Amy; Gallagher, Michael; Manis, John; Khamlichi, Ahmed Amine; Alt, Frederick (National Academy of Sciences, 2010)Ig heavy chain (IgH) class-switch recombination(CSR) replaces the IgH C mu constant region exons with one of several sets of downstream IgH constant region exons (e. g., C gamma, C epsilon, or C alpha), which affects ... -
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
Cheng, Hwei-Ling; Vuong, Bao; Basu, Uttiya; Franklin, Andrew; Schwer, Bjoern; Astarita, Jillian; Phan, Ryan; Datta, Abhishek; Manis, John; Alt, Frederick; Chaudhuri, Jayanta (National Academy of Sciences, 2009)Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) and Ig somatic hypermutation (SHM) by deaminating ...