Browsing Harvard Medical School by Author "Cooke, Susanna L."

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    • Mutational signatures of ionizing radiation in second malignancies 

      Behjati, Sam; Gundem, Gunes; Wedge, David C.; Roberts, Nicola D.; Tarpey, Patrick S.; Cooke, Susanna L.; Van Loo, Peter; Alexandrov, Ludmil B.; Ramakrishna, Manasa; Davies, Helen; Nik-Zainal, Serena; Hardy, Claire; Latimer, Calli; Raine, Keiran M.; Stebbings, Lucy; Menzies, Andy; Jones, David; Shepherd, Rebecca; Butler, Adam P.; Teague, Jon W.; Jorgensen, Mette; Khatri, Bhavisha; Pillay, Nischalan; Shlien, Adam; Futreal, P. Andrew; Badie, Christophe; Cooper, Colin S.; Eeles, Rosalind A.; Easton, Douglas; Foster, Christopher; Neal, David E.; Brewer, Daniel S.; Hamdy, Freddie; Lu, Yong-Jie; Lynch, Andrew G.; Massi, Charlie E.; Ng, Anthony; Whitaker, Hayley C.; Yu, Yongwei; Zhang, Hongwei; Bancroft, Elizabeth; Berney, Dan; Camacho, Niedzica; Corbishley, Cathy; Dadaev, Tokhir; Dennis, Nening; Dudderidge, Tim; Edwards, Sandra; Fisher, Cyril; Ghori, Jilur; Gnanapragasam, Vincent J.; Greenman, Christopher; Hawkins, Steve; Hazell, Steven; Howat, Will; Karaszi, Katalin; Kay, Jonathan; Kote-Jarai, Zsofia; Kremeyer, Barbara; Kumar, Pardeep; Lambert, Adam; Leongamornlert, Daniel; Livni, Naomi; Luxton, Hayley; Matthews, Lucy; Mayer, Erik; Merson, Susan; Nicol, David; Ogden, Christopher; O'Meara, Sarah; Pelvender, Gill; Shah, Nimish C.; Tavare, Simon; Thomas, Sarah; Thompson, Alan; Verrill, Claire; Warren, Anne; Zamora, Jorge; McDermott, Ultan; Bova, G. Steven; Richardson, Andrea L.; Flanagan, Adrienne M.; Stratton, Michael R.; Campbell, Peter J. (Nature Publishing Group, 2016)
      Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...