Browsing Harvard Medical School by Title

Now showing items 11797-11816 of 18442

    • The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery 

      Zada, Gabriel; Agarwalla, Pankaj Kumar; Mukundan, Srinivasan; Dunn, Ian Frederick; Golby, Alexandra J.; Laws, Edward R. (Journal of Neurosurgery Publishing Group (JNSPG), 2011)
      Object A considerable degree of variability exists in the anatomy of the sphenoid sinus, sella turcica, and surrounding skull base structures. The authors aimed to characterize neuroimaging and intraoperative variations ...

    • Neurotic, a Novel Maternal Neurogenic Gene, Encodes an O-Fucosyltransferase That Is Essential for Notch-Delta Interactions 

      Sasamura, Takeshi; Sasaki, Nobuo; Miyashita, Fumiyasu; Nakao, Shiho; Ishikawa, Hiroyuki O.; Ito, Mikiko; Kitagawa, Motoo; Harigaya, Kenichi; Spana, Eric; Bilder, David; Perrimon, Norbert; Matsuno, Kenji (The Company of Biologists, 2003-10-15)
      Notch signalling, which is highly conserved from nematodes to mammals, plays crucial roles in many developmental processes. In the Drosophila embryo, deficiency in Notch signalling results in neural hyperplasia, commonly ...

    • Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma 

      Wan, Guoqiang; Gómez-Casati, Maria E; Gigliello, Angelica R; Liberman, M Charles; Corfas, Gabriel (eLife Sciences Publications, Ltd, 2014)
      Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal ...

    • Neurovascular Network Explorer 1.0: a database of 2-photon single-vessel diameter measurements with MATLAB® graphical user interface 

      Sridhar, Vishnu B.; Tian, Peifang; Dale, Anders M.; Devor, Anna; Saisan, Payam A. (Frontiers Media S.A., 2014)
      We present a database client software—Neurovascular Network Explorer 1.0 (NNE 1.0)—that uses MATLAB® based Graphical User Interface (GUI) for interaction with a database of 2-photon single-vessel diameter measurements from ...

    • The Neurovascular Relation in Oxygen-induced Retinopathy 

      Akula, James Daniel; Mocko, Julie A.; Benador, Ilan Y.; Hansen, Ronald M.; Favazza, Tara L.; Vyhovsky, Tanya C.; Fulton, Anne Bailey (Molecular Vision, 2008)
      Purpose: Longitudinal studies in rat models of retinopathy of prematurity (ROP) have demonstrated that abnormalities of retinal vasculature and function change hand-in-hand. In the developing retina, vascular and neural ...

    • Neutralizing Anti-HIV Antibodies Develop in a Humanized Mouse Model of HIV-1 Infection 

      Vrbanac, Vladimir; Tivey, T; Cariappa, A; Seung, Edward N.; Dugast, Anne-Sophie; Dudek, Timothy E; Mattoo, Hamid Rasheed; Murooka, Thomas; Pillai, Shiv Subramaniam; Tager, Andrew Martin; Luster, Andrew David (BioMed Central, 2012)

    • Neutralizing Antibodies Against West Nile Virus Identified Directly From Human B Cells by Single-Cell Analysis and Next Generation Sequencing 

      Tsioris, Konstantinos; Gupta, Namita T.; Ogunniyi, Adebola O.; Zimnisky, Ross M.; Qian, Feng; Yao, Yi; Wang, Xiaomei; Stern, Joel N. H.; Chari, Raj; Briggs, Adrian W.; Clouser, Christopher R.; Vigneault, Francois; Church, George; Garcia, Melissa N.; Murray, Kristy O.; Montgomery, Ruth R.; Kleinstein, Steven H.; Love, J. Christopher (Royal Society of Chemistry (RSC), 2015-12-30)
      West Nile virus infection (WNV) is an emerging mosquito-borne disease that can lead to severe neurological illness and currently has no available treatment or vaccine. Using microengraving, an integrated single-cell analysis ...

    • Neutrophil Apoptosis and Its Involvement in Inflammation and Infection 

      Loison, Fabien; Luo, Hongbo (CRC Press, 2010)
      Neutrophil accumulation at inflammatory sites is an important component of innate immunity and is required for the host’s ability to kill invading pathogens. However, exaggerated neutrophil accumulation can also lead to ...

    • Neutrophil extracellular traps 

      Demers, Mélanie; Wagner, Denisa D. (Landes Bioscience, 2013)
      Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) ...

    • Neutrophil Responses to Sterile Implant Materials 

      Jhunjhunwala, Siddharth; Aresta-DaSilva, Stephanie; Tang, Katherine; Alvarez, David; Webber, Matthew J.; Tang, Benjamin C.; Lavin, Danya M.; Veiseh, Omid; Doloff, Joshua C.; Bose, Suman; Vegas, Arturo; Ma, Minglin; Sahay, Gaurav; Chiu, Alan; Bader, Andrew; Langan, Erin; Siebert, Sean; Li, Jie; Greiner, Dale L.; Newburger, Peter E.; von Andrian, Ulrich H.; Langer, Robert; Anderson, Daniel G. (Public Library of Science, 2015)
      In vivo implantation of sterile materials and devices results in a foreign body immune response leading to fibrosis of implanted material. Neutrophils, one of the first immune cells to be recruited to implantation sites, ...

    • Neutrophil Spontaneous Death Is Mediated by Down-Regulation of Autocrine Signaling through GPCR, PI3K\(\gamma\), ROS, and actin 

      Xu, Yuanfu; Loison, Fabien; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2010)
      Neutrophil spontaneous apoptosis plays a crucial role in neutrophil homeostasis and the resolution of inflammation. We previously established Akt deactivation as a key mediator of this tightly regulated cellular death ...

    • Neutrophil-Mediated Experimental Metastasis Is Enhanced by VEGFR Inhibition in a Zebrafish Xenograft Model 

      He, Shuning; Lamers, Gerda EM; Beenakker, Jan-Willem M; Cui, Chao; Ghotra, Veerander PS; Danen, Erik HJ; Meijer, Annemarie H; Spaink, Herman P; Snaar-Jagalska, B Ewa (John Wiley & Sons, 2012)
      Inhibition of VEGF signalling effectively suppresses localized tumour growth but accelerates tumour invasiveness and micrometastasis by unknown mechanisms. To study the dynamic and reciprocal interactions between tumour ...

    • New Advances in Urogynecology 

      Lowenstein, Lior; Rosenblatt, Peter L.; Dietz, Hans Peter; Bitzer, Johannes; Kenton, Kimberly (Hindawi Publishing Corporation, 2012)

    • New Approaches to Eliciting Protective Immunity Through T Cell Repertoire Manipulation: The Concept of Thymic Vaccination 

      Fridkis-Hareli, Masha; Reinherz, Ellis Leonard (BioMed Central, 2004)
      Conventional vaccines afford protection against infectious diseases by expanding existing pathogen-specific peripheral lymphocytes, both CD8 cytotoxic effector (CTL) and CD4 helper T cells. The latter induce B cell maturation ...

    • A New Class of Small Molecule Inhibitor of BMP Signaling 

      Sanvitale, Caroline E.; Kerr, Georgina; Chaikuad, Apirat; Ramel, Marie-Christine; Mohedas, Agustin Humberto; Reichert, Sabine; Wang, You; Triffitt, James T.; Cuny, Gregory D.; Yu, Paul B.; Hill, Caroline S.; Bullock, Alex N. (Public Library of Science, 2013)
      Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor ...

    • New Clathrin-Based Nanoplatforms for Magnetic Resonance Imaging 

      Vitaliano, Franco; Vitaliano, Gordana Dragan; Rios, Jose D.; Renshaw, Perry Franklin; Teicher, Martin Hersch (Public Library of Science, 2012)
      Background: Magnetic Resonance Imaging (MRI) has high spatial resolution, but low sensitivity for visualization of molecular targets in the central nervous system (CNS). Our goal was to develop a new MRI method with the ...

    • A New Concept for Cancer Therapy: Out-Competing the Aggressor 

      Deisboeck, Thomas Steve; Wang, Zhihui (BioMed Central, 2008)
      Cancer expansion depends on host organ conditions that permit growth. Since such microenvironmental nourishment is limited we argue here that an autologous, therapeutically engineered and faster metabolizing cell strain ...

    • A New Dawn for Industrial Photosynthesis 

      Robertson, Dan E.; Jacobson, Stuart A.; Morgan, Frederick; Berry, David; Church, George McDonald; Afeyan, Noubar (Springer Netherlands, 2011)
      Several emerging technologies are aiming to meet renewable fuel standards, mitigate greenhouse gas emissions, and provide viable alternatives to fossil fuels. Direct conversion of solar energy into fungible liquid fuel is ...

    • New developments in the treatment of metastatic melanoma – role of dabrafenib–trametinib combination therapy 

      Luke, Jason J; Ott, Patrick A (Dove Medical Press, 2014)
      Development of selective inhibitors of BRAF has improved the survival of patients with BRAF-mutant melanoma. The progression-free survival after treatment with a BRAF inhibitor is modest, however, and BRAF inhibitors induce ...

    • New dimensions and new tools to realize the potential of RDoC: digital phenotyping via smartphones and connected devices 

      Torous, John B.; Onnela, J-P; Keshavan, Matcheri S (Springer Nature, 2017)
      Mobile and connected devices like smartphones and wearable sensors can facilitate the collection of novel naturalistic and longitudinal data relevant to psychiatry at both the personal and population level. The National ...