Browsing Harvard Medical School by Title

Now showing items 16414-16433 of 18428

    • Sub-threshold depression and antidepressants use in a community sample: searching anxiety and finding bipolar disorder 

      Carta, Mauro G.; Tondo, Leonardo; Balestrieri, Matteo; Caraci, Filippo; dell'Osso, Liliana; Di Sciascio, Guido; Faravelli, Carlo; Hardoy, Maria Carolina; Lecca, Maria E.; Moro, Maria Francesca; Bhat, Krishna M.; Casacchia, Massimo; Drago, Filippo (BMC, 2011)
      Background: To determine the use of antidepressants (ADs) in people with sub-threshold depression (SD); the lifetime prevalence of mania and hypomania in SD and the link between ADs use, bipolarity and anxiety disorders ...

    • Subacute Bacterial Endocarditis with Leptotrichia goodfellowii in a Patient with a Valvular Allograft: A Case Report and Review of the Literature 

      Matias, Wilfredo R.; Bourque, Daniel L.; Niwano, Tomoko; Onderdonk, Andrew B.; Katz, Joel T. (Hindawi Publishing Corporation, 2016)
      Leptotrichia species are normal constituents of the oral cavity and the genitourinary tract microbiota that are known to provoke disease in immunocompromised patients and rarely in immunocompetent individuals. Following ...

    • Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling 

      Koide, Masayo; Sukhotinsky, Inna; Ayata, Cenk; Wellman, George C. (Hindawi Publishing Corporation, 2013)
      Aneurysmal subarachnoid hemorrhage (SAH) has devastating consequences on brain function including profound effects on communication between neurons and the vasculature leading to cerebral ischemia. Physiologically, ...

    • Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex 

      Poulopoulos, Alexandros; Murphy, Alexander; Ozkan, Abdulkadir; Davis, Chris; Hatch, John; Kirchner, Rory; Macklis, Jeffrey; Murphy, Alexander (Springer Science and Business Media LLC, 2019-01)
      The development of neural circuits relies on axon projections establishing diverse, yet well-defined, connections between areas of the nervous system. Each projection is formed by growth cones—subcellular specializations ...

    • The subchondral bone in articular cartilage repair: current problems in the surgical management 

      Gomoll, Andreas H.; Madry, Henning; Knutsen, Gunnar; van Dijk, Niek; Seil, Romain; Brittberg, Mats; Kon, Elizaveta (Springer-Verlag, 2010)
      As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing ...

    • Subclassification of Autoimmune Pancreatitis: A Histologic Classification With Clinical Significance 

      Deshpande, Vikram; Gupta, Rajib; Sainani, Nisha I.; Sahani, Dushyant V.; Virk, Renu; Ferrone, Cristina Rosa; Khosroshahi, Arezou; Stone, John H; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Autoimmune pancreatitis (AIP) is a chronic inflammatory disease of the pancreas. Examination of pancreatic resection specimens from patients with AIP has shown that there are 2 subclasses of this disease. However, there ...

    • Subclinical Left Ventricular Dysfunction in Preeclamptic Women With Preserved Left Ventricular Ejection Fraction 

      Shahul, Sajid; Rhee, Julie; Gulati, Gaurav; Hess, Philip; Mahmood, Feroze-Ud-Den; Arany, Zolt; Rana, Sarosh; Talmor, Daniel; Hacker, Michele; Mitchell, John (Ovid Technologies (Wolters Kluwer Health), 2012-11)
      Background-Patients with preeclampsia are at risk for cardiovascular disease. Changes in cardiac function are subtle in preeclampsia and are difficult to quantify with conventional imaging. Strain measurements using ...

    • Subclonal Cooperation Drives Metastasis by Modulating Local and Systemic Immune Microenvironments 

      Cristea, Simona; Kwak, Minsuk; Qin, Yuanbo; Laszewski, Tyler; Luoma, Adrienne; Marusyk, Andriy; Wagle, Nikhil; Fang, Rongxin; Polyak, Kornelia; Janiszewska, Michalina; Tabassum, Doris; Castaño, Zafira; Yamamoto, Kimiyo; Kingston, Natalie; Murphy, Katherine; Shu, Shaokun; Harper, Nicholas; Gil del Alcazar, Carlos; Alečković, Maša; Ekram, Muhammad; Cohen, Ofir; Cohen, Ofir; Wucherpfennig, Kai; Michor, Franziska; McAllister, Sandra (Springer Science and Business Media LLC, 2019-07)
      Most human tumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumours have poor clinical outcomes, yet the underlying mechanism remains ...

    • Subclonal diversification of primary breast cancer revealed by multiregion sequencing 

      Yates, Lucy R; Gerstung, Moritz; Knappskog, Stian; Desmedt, Christine; Gundem, Gunes; Loo, Peter Van; Aas, Turid; Alexandrov, Ludmil B; Larsimont, Denis; Davies, Helen; Li, Yilong; Ju, Young Seok; Ramakrishna, Manasa; Haugland, Hans Kristian; Lilleng, Peer Kaare; Nik-Zainal, Serena; McLaren, Stuart; Butler, Adam; Martin, Sancha; Glodzik, Dominic; Menzies, Andrew; Raine, Keiran; Hinton, Jonathan; Jones, David; Mudie, Laura J; Jiang, Bing; Vincent, Delphine; Greene-Colozzi, April; Adnet, Pierre-Yves; Fatima, Aquila; Maetens, Marion; Ignatiadis, Michail; Stratton, Michael R; Sotiriou, Christos; Richardson, Andrea L; Lønning, Per Eystein; Wedge, David C; Campbell, Peter J (2015)
      Sequencing cancer genomes may enable tailoring of therapeutics to the underlying biological abnormalities driving a particular patient’s tumor. However, sequencing-based strategies rely heavily on representative sampling ...

    • Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium 

      van Erp, T G M; Hibar, D P; Rasmussen, J M; Glahn, D C; Pearlson, G D; Andreassen, O A; Agartz, I; Westlye, L T; Haukvik, U K; Dale, A M; Melle, I; Hartberg, C B; Gruber, O; Kraemer, B; Zilles, D; Donohoe, G; Kelly, S; McDonald, C; Morris, D W; Cannon, D M; Corvin, A; Machielsen, M W J; Koenders, L; de Haan, L; Veltman, D J; Satterthwaite, T D; Wolf, D H; Gur, R C; Gur, R E; Potkin, S G; Mathalon, D H; Mueller, B A; Preda, A; Macciardi, F; Ehrlich, S; Walton, E; Hass, J; Calhoun, V D; Bockholt, H J; Sponheim, S R; Shoemaker, J M; van Haren, N E M; Pol, H E H; Ophoff, R A; Kahn, R S; Roiz-Santiañez, R; Crespo-Facorro, B; Wang, L; Alpert, K I; Jönsson, E G; Dimitrova, R; Bois, C; Whalley, H C; McIntosh, A M; Lawrie, S M; Hashimoto, R; Thompson, P M; Turner, J A (Nature Publishing Group, 2016)
      The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter ...

    • Subcortical Ischemic Vascular Disease: Roles of Oligodendrocyte Function in Experimental Models of Subcortical White-Matter Injury 

      Shindo, Akihiro; Liang, Anna C; Maki, Takakuni; Miyamoto, Nobukazu; Tomimoto, Hidekazu; Lo, Eng; Arai, Ken (SAGE Publications, 2015-04-29)
      Oligodendrocytes are one of the major cell types in cerebral white matter. Under normal conditions, they form myelin sheaths that encircle axons to support fast nerve conduction. Under conditions of cerebral ischemia, ...

    • Subcutaneous fat thickness, but not epicardial fat thickness, parallel weight reduction after bariatric surgery: a cardiac magnetic resonance study 

      Foppa, Murilo; Pond, Kyle K.; Jones, Daniel Bougere; Kissinger, Kraig V; Goddu, Beth; Schneider, Benjamin Edward; Jhaveri, Rahul; Manning, Warren J. (BioMed Central, 2013)

    • Subgenual Cingulate Cortex Volume in First-Episode Psychosis 

      Hirayasu, Yoshio; Shenton, Martha Elizabeth; Salisbury, Dean F.; Soo Kwon, Jun; Wible, Cynthia Gayle; Fischer, Iris A.; Yurgelun-Todd, Deborah; Zarate, Carlos; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William (American Psychiatric Publishing, 1999)
      Objective: Gray matter volume and glucose utilization have been reported to be reduced in the left subgenual cingulate of subjects with familial bipolar or unipolar depression. It is unclear whether these findings are ...

    • Subjective Mood in Young Unmedicated Depressed Women under High and Low Sleep Pressure Conditions 

      Birchler-Pedross, Angelina; Frey, Sylvia; Götz, Thomas; Brunner, Patrick; Knoblauch, Vera; Wirz-Justice, Anna; Chellappa, Sarah L.; Cajochen, Christian (MDPI, 2016)
      Diurnal mood variations are one of the core symptoms in depression, and total sleep deprivation (SD) can induce rapid, short-lasting clinical improvement in depressed patients. Here, we investigated if differential sleep ...

    • Subjective symptomatology in nasal obstruction and the impact of septorhinoplasty with spreader graft placement on patient-perceived nasal appearance and nasal obstruction 

      Weitzman, Rachel (2021)

    • Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells 

      Choi, Young Eun; Battelli, Chiara; Watson, Jacqueline; Liu, Joyce; Curtis, Jennifer; Morse, Alexander N.; Matulonis, Ursula A.; Chowdhury, Dipanjan; Konstantinopoulos, Panagiotis A. (Impact Journals LLC, 2014)
      The promise of PARP-inhibitors(PARPis) in the management of epithelial ovarian cancer(EOC) is tempered by the fact that approximately 50% of patients with homologous recombination (HR)-proficient tumors do not respond well ...

    • Sublingual Nitroglycerin Administration in Coronary Computed Tomography Angiography: a Systematic Review 

      Takx, Richard A. P.; Suchá, Dominika; Park, Jakob; Leiner, Tim; Hoffmann, Udo (Springer Berlin Heidelberg, 2015)
      Objective: To systematically investigate the literature for the influence of sublingual nitroglycerin administration on coronary diameter, the number of evaluable segments, image quality, heart rate and blood pressure, and ...

    • Submaximal Exercise Systolic Blood Pressure and Heart Rate at 20 Years of Follow‐up: Correlates in the Framingham Heart Study 

      Spartano, Nicole L.; Lyass, Asya; Larson, Martin G.; Lewis, Gregory D.; Vasan, Ramachandran S. (John Wiley and Sons Inc., 2016)
      Background: Beyond their resting values, exercise responses in blood pressure (BP) and heart rate (HR) may add prognostic information for cardiovascular disease (CVD). In cross‐sectional studies, exercise BP and HR responses ...

    • Submicrometre Geometrically Encoded Fluorescent Barcodes Self-Assembled From DNA 

      Lin, Chenxiang; Jungmann, Ralf; Leifer, Andrew M.; Li, Chao; Levner, Daniel; Church, George; Shih, William; Yin, Peng (Springer Science and Business Media LLC, 2012-10)
      The identification and differentiation of a large number of distinct molecular species with high temporal and spatial resolution is a major challenge in biomedical science. Fluorescence microscopy is a powerful tool, but ...

    • Suboptimal Clinical Documentation in Young Children with Severe Obesity at Tertiary Care Centers 

      Brady, Cassandra C.; Thaker, Vidhu V.; Lingren, Todd; Woo, Jessica G.; Kennebeck, Stephanie S.; Namjou-Khales, Bahram; Roach, Ashton; Bickel, Jonathan P.; Patibandla, Nandan; Savova, Guergana K.; Solti, Imre; Holm, Ingrid A.; Harley, John B.; Kohane, Isaac S.; Crimmins, Nancy A. (Hindawi Publishing Corporation, 2016)
      Background and Objectives. The prevalence of severe obesity in children has doubled in the past decade. The objective of this study is to identify the clinical documentation of obesity in young children with a BMI ≥ 99th ...