Browsing Harvard Medical School by Title

Now showing items 5799-5818 of 18442

    • Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma 

      Suehiro, Yutaka; Wong, Chi Wai; Chirieac, Lucian; Kondo, Yutaka; Shen, Lanlan; Webb, C. Renee; Chan, Yee Wai; Chan, Annie S.Y.; Chan, Tsun Leung; Wu, Tsung-Teh; Rashid, Asif; Hamanaka, Yuichiro; Hinoda, Yuji; Shannon, Rhonda L.; Wang, Xuemei; Morris, Jeffrey; Issa, Jean-Pierre J.; Yuen, Siu Tsan; Leung, Suet Yi; Hamilton, Stanley R. (American Association for Cancer Research (AACR), 2008-05-01)
      Purpose Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O6-methylguanine DNA methyltransferase ...

    • Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling 

      Liu, Philip K.; Liu, Christina H. (BioMed Central, 2016)
      Background: Histone deacetylase (HDAC) activities modify chromatin structure and play a role in learning and memory during developmental processes. Studies of adult mice suggest HDACs are involved in neural network remodeling ...

    • Epigenetics—a potential mediator between air pollution and preterm birth 

      Lin, Vania W.; Baccarelli, Andrea A.; Burris, Heather H. (2016)
      Preterm birth is a major cause of infant morbidity and mortality and a potential risk factor for adult chronic disease. With over 15 million infants born preterm worldwide each year, preterm birth poses a global health ...

    • Epigenome-wide and transcriptome-wide analyses reveal gestational diabetes is associated with alterations in the human leukocyte antigen complex 

      Binder, Alexandra M.; LaRocca, Jessica; Lesseur, Corina; Marsit, Carmen J.; Michels, Karin B. (BioMed Central, 2015)
      Background: Gestational diabetes mellitus (GDM) affects approximately 10 % of pregnancies in the United States and increases the risk of adverse health outcomes in the offspring. These adult disease propensities may be set ...

    • Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis 

      Zhou, Fusheng; Shen, Changbing; Xu, Jingkai; Gao, Jing; Zheng, Xiaodong; Ko, Randy; Dou, Jinfa; Cheng, Yuyan; Zhu, Caihong; Xu, Shuangjun; Tang, Xianfa; Zuo, Xianbo; Yin, Xianyong; Cui, Yong; Sun, Liangdan; Tsoi, Lam C.; Hsu, Yi-Hsiang; Yang, Sen; Zhang, Xuejun (BioMed Central, 2016)
      Background: Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and altered keratinocyte differentiation and inflammation and is caused by the interplay of genetic and environmental ...

    • The epigenome: the next substrate for engineering 

      Park, Minhee; Keung, Albert J.; Khalil, Ahmad S. (BioMed Central, 2016)
      We are entering an era of epigenome engineering. The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogate their influence on genome and cell function and to harness these changes ...

    • An epigenomic approach to therapy for tamoxifen-resistant breast cancer 

      Feng, Qin; Zhang, Zheng; Shea, Martin J; Creighton, Chad J; Coarfa, Cristian; Hilsenbeck, Susan G; Lanz, Rainer; He, Bin; Wang, Lei; Fu, Xiaoyong; Nardone, Agostina; Song, Yongcheng; Bradner, James; Mitsiades, Nicholas; Mitsiades, Constantine S; Osborne, C Kent; Schiff, Rachel; O'Malley, Bert W (Nature Publishing Group, 2014)
      Tamoxifen has been a frontline treatment for estrogen receptor alpha (ERα)-positive breast tumors in premenopausal women. However, resistance to tamoxifen occurs in many patients. ER still plays a critical role in the ...

    • Epigenomic Diversity of Colorectal Cancer Indicated by LINE-1 Methylation in a Database of 869 Tumors 

      Baba, Yoshifumi; Huttenhower, Curtis; Nosho, Katsuhiko; Tanaka, Noriko; Shima, Kaori; Hazra, Aditi; Schernhammer, Eva S; Hunter, David J.; Giovannucci, Edward L.; Fuchs, Charles Stewart; Ogino, Shuji (BioMed Central, 2010)
      Background: Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with ...

    • EpiGraph Pan-coronavirus Vaccine: An Immunogenicity Study of Computationally-Predicted Antigen Vaccine in Mice 

      Zhou, Zhiqian (2023-05-10)
      In late 2019, a highly transmissible and pathogenic RNA virus termed Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the Hubei province of China causing the coronavirus disease (COVID-19), which ...

    • Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure 

      Sharkey, Mark; Babic, Dunja Z.; Greenough, Thomas; Gulick, Roy; Stevenson, Mario; Cullen, Bryan R.; Kuritzkes, Daniel Robert (Public Library of Science, 2011)
      Viral reservoirs that persist in HIV-1 infected individuals on antiretroviral therapy (ART) are the major obstacle to viral eradication. The identification and definition of viral reservoirs in patients on ART is needed ...

    • Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium 

      Verma, Shefali Setia; Cooke Bailey, Jessica N.; Lucas, Anastasia; Bradford, Yuki; Linneman, James G.; Hauser, Michael A.; Pasquale, Louis R.; Peissig, Peggy L.; Brilliant, Murray H.; McCarty, Catherine A.; Haines, Jonathan L.; Wiggs, Janey L.; Vrabec, Tamara R.; Tromp, Gerard; Ritchie, Marylyn D. (Public Library of Science, 2016)
      Primary open angle glaucoma (POAG) is a complex disease and is one of the major leading causes of blindness worldwide. Genome-wide association studies have successfully identified several common variants associated with ...

    • The Epistemology of Quality Improvement: It's All Greek 

      Perla, Rocco J; Parry, Gareth John (BMJ Group, 2011)
      In Plato's Theaetetus, knowledge is defined as the intersection of truth and belief, where knowledge cannot be claimed if something is true but not believed or believed but not true. Using an example from neonatal intensive ...

    • Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis 

      Patel, Avignat S.; Song, Jin Woo; Chu, Sarah G.; Mizumura, Kenji; Osorio, Juan C.; Shi, Ying; El-Chemaly, Souheil; Lee, Chun Geun; Rosas, Ivan O.; Elias, Jack A.; Choi, Augustine M. K.; Morse, Danielle (Public Library of Science, 2015)
      Background: Epithelial cell death is a major contributor to fibrogenesis in the lung. In this study, we sought to determine the function of mitochondria and their clearance (mitophagy) in alveolar epithelial cell death and ...

    • Epithelial Ovarian Cancer Stem Cells---A Review 

      Pan, Yueyin; Huang, Xudong (2008-06-30)
      Ovarian cancer is the fifth leading cause of cancer deaths among women and the most common type of gynecologic malignancy. Despite advances in surgery and chemotherapy, the survival rate of patients with epithelial ovarian ...

    • The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations 

      Agrawal, Pankaj; Wang, Ruobing; Li, Hongmei Lisa; Schmitz Abe, Klaus; Simone-Roach, Chantelle; Chen, Jingxin; Shi, Jiahai; Louie, Tin; Sheng, Shaohu; Towne, Meghan C.; Brainson, Christine F.; Matthay, Michael A.; Kim, Carla; Bamshad, Michael; Emond, Mary J.; Gerard, Norma; Kleyman, Thomas R.; Gerard, Craig; Kleyman, Thomas (American Thoracic Society, 2017-12)
      Cystic fibrosis (CF) remains the most lethal genetic disease in the Caucasian population. However, there is great variability in clinical phenotypes and survival times, even among patients harboring the same genotype. We ...

    • EPITHELIAL WNT SIGNALING DRIVES THE PROGRESSION OF DSS-INDUCED COLITIS IN MURINE MODEL 

      Jackson, Sergio (2023-05-10)
      Ulcerative colitis (UC) is a complex disease that involves a dysregulated immune response. Increased intestinal permeability resulting in inflammation is well established in the study of colitis. In addition, Wnt/ß-signaling ...

    • Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk 

      Amankwah, Ernest K.; Lin, Hui-Yi; Tyrer, Jonathan P.; Lawrenson, Kate; Dennis, Joe; Chornokur, Ganna; Aben, Katja K. H.; Anton-Culver, Hoda; Antonenkova, Natalia; Bruinsma, Fiona; Bandera, Elisa V.; Bean, Yukie T.; Beckmann, Matthias W.; Bisogna, Maria; Bjorge, Line; Bogdanova, Natalia; Brinton, Louise A.; Brooks-Wilson, Angela; Bunker, Clareann H.; Butzow, Ralf; Campbell, Ian G.; Carty, Karen; Chen, Zhihua; Chen, Y. Ann; Chang-Claude, Jenny; Cook, Linda S.; Cramer, Daniel William; Cunningham, Julie M.; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; du Bois, Andreas; Despierre, Evelyn; Dicks, Ed; Doherty, Jennifer A.; Dörk, Thilo; Dürst, Matthias; Easton, Douglas F.; Eccles, Diana M.; Edwards, Robert P.; Ekici, Arif B.; Fasching, Peter A.; Fridley, Brooke L.; Gao, Yu-Tang; Gentry-Maharaj, Aleksandra; Giles, Graham G.; Glasspool, Rosalind; Goodman, Marc T.; Gronwald, Jacek; Harrington, Patricia; Harter, Philipp; Hasmad, Hanis N.; Hein, Alexander; Heitz, Florian; Hildebrandt, Michelle A. T.; Hillemanns, Peter; Hogdall, Claus K.; Hogdall, Estrid; Hosono, Satoyo; Iversen, Edwin S.; Jakubowska, Anna; Jensen, Allan; Ji, Bu-Tian; Karlan, Beth Y.; Jim, Heather; Kellar, Melissa; Kiemeney, Lambertus A.; Krakstad, Camilla; Kjaer, Susanne K.; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D.; Lee, Alice W.; Lele, Shashi; Leminen, Arto; Lester, Jenny; Levine, Douglas A.; Liang, Dong; Lim, Boon Kiong; Lissowska, Jolanta; Lu, Karen; Lubinski, Jan; Lundvall, Lene; Massuger, Leon F. A. G.; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R.; McNeish, Ian; Menon, Usha; Milne, Roger L.; Modugno, Francesmary; Moysich, Kirsten B.; Ness, Roberta B.; Nevanlinna, Heli; Eilber, Ursula; Odunsi, Kunle; Olson, Sara H.; Orlow, Irene; Orsulic, Sandra; Weber, Rachel Palmieri; Paul, James; Pearce, Celeste L.; Pejovic, Tanja; Pelttari, Liisa M.; Permuth-Wey, Jennifer; Pike, Malcolm C.; Poole, Elizabeth M.; Risch, Harvey A.; Rosen, Barry; Rossing, Mary Anne; Rothstein, Joseph H.; Rudolph, Anja; Runnebaum, Ingo B.; Rzepecka, Iwona K.; Salvesen, Helga B.; Schernhammer, Eva S; Schwaab, Ira; Shu, Xiao-Ou; Shvetsov, Yurii B.; Siddiqui, Nadeem; Sieh, Weiva; Song, Honglin; Southey, Melissa C.; Spiewankiewicz, Beata; Sucheston-Campbell, Lara; Teo, Soo-Hwang; Terry, Kathryn Lynne; Thompson, Pamela J.; Thomsen, Lotte; Tangen, Ingvild L.; Tworoger, Shelley Slate; van Altena, Anne M.; Vierkant, Robert A.; Vergote, Ignace; Walsh, Christine S.; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S.; Wicklund, Kristine G.; Wilkens, Lynne R.; Wu, Anna H.; Wu, Xifeng; Woo, Yin-Ling; Yang, Hannah; Zheng, Wei; Ziogas, Argyrios; Kelemen, Linda E.; Berchuck, Andrew; Schildkraut, Joellen M.; Ramus, Susan J.; Goode, Ellen L.; Monteiro, Alvaro N. A.; Gayther, Simon A.; Narod, Steven A.; Pharoah, Paul D. P.; Sellers, Thomas A.; Phelan, Catherine M. (Wiley-Blackwell, 2015)
      Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary ...

    • The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming 

      Unternaehrer, Juli J.; Zhao, Rui; Kim, Kitai; Cesana, Marcella; Powers, John T.; Ratanasirintrawoot, Sutheera; Onder, Tamer; Shibue, Tsukasa; Weinberg, Robert A.; Daley, George Q. (Elsevier, 2014)
      Summary Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that ...

    • Epitope Specificity Appears To Be an Important Determinant of In Vivo Killing Ability of Simian Immunodeficiency Virus (SIV)-Specific CD8+ T Cells 

      Pozzi, L; Carville, A; Varner, Valerie Hogan; Sen, Jayita; Knipe, David Mahan; Kaur, Amitinder (BioMed Central, 2012)

    • Epitope-Based Vaccines: SARS – A Model 

      Freund, Natalia Tarnovitski; Sui, Jianhua; Marasco, Wayne A.; Gershoni, Jonathan M (BioMed Central, 2006)