Browsing Harvard Medical School by Keyword "COX-2"

Now showing items 1-2 of 2

    • Celecoxib inhibits early cutaneous wound healing 

      Fairweather, Mark; Heit, Yvonne I.; Buie, Justin David; Rosenberg, Laura Michele; Briggs, Alexandra; Orgill, Dennis Paul; Bertagnolli, Monica Marie (Elsevier BV, 2015)
      BACKGROUND: Cyclooxygenase-2 (COX-2) is an inducible enzyme that is rapidly upregulated in response to injury, resulting in the production of prostaglandin E2 (PGE2), a primary mediator of inflammation and wound healing. ...

    • EGF-R is Expressed and AP-1 and NF-κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX-2 and VEGF 

      Konstantinopoulos, Panagiotis A.; Vandoros, Gerasimos P.; Karamouzis, Michalis V.; Gkermpesi, Maria; Sotiropoulou-Bonikou, Georgia; Papavassiliou, Athanasios G. (IOS Press, 2007)
      Background:: COX-2 and VEGF are important triggers of colon cancer growth, metastasis and angiogenesis. Cox-2 promoter contains transcriptional regulatory elements for AP-1 and NF-κ:B transcription factors whilst vegf is ...