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Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice
(Ovid Technologies (Wolters Kluwer Health), 2011)
Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ...
Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice
(Ovid Technologies (Wolters Kluwer Health), 2011)
Objective—The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. ...