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The sodium channel band shapes the response to electric stimulation in retinal ganglion cells
(IOP Publishing, 2011-05-11)
Electric stimulation of the retina reliably elicits light percepts in patients blinded by outer retinal diseases. However, individual percepts are highly variable and do not readily assemble into more complex visual images. ...
Multiple components of ganglion cell desensitization in response to prosthetic stimulation
(IOP Publishing, 2011-01-19)
Retinal prostheses aim to restore functional vision to those blinded by outer retinal diseases using electric stimulation of surviving neurons. Previous work indicates that repetitive stimulation with stimuli that activate ...
Calcium channel dynamics limit synaptic release in response to prosthetic stimulation with sinusoidal waveforms
(IOP Publishing, 2011-05-31)
Extracellular electric stimulation with sinusoidal waveforms has been shown to allow preferential activation of individual types of retinal neurons by varying stimulus frequency. It is important to understand the mechanisms ...
Encoding visual information in retinal ganglion cells with prosthetic stimulation
(IOP Publishing, 2011-05-18)
Retinal prostheses aim to restore functional vision to those blinded by outer retinal diseases using electric stimulation of surviving retinal neurons. The ability to replicate the spatiotemporal pattern of ganglion cell ...
Differential responses to high-frequency electrical stimulation in ON and OFF retinal ganglion cells
(IOP Publishing, 2014-02-21)
Objective
The field of retinal prosthetics for artificial vision has advanced considerably in recent years, however clinical outcomes remain inconsistent. The performance of retinal prostheses is likely limited by the ...
Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells
(Springer Science and Business Media LLC, 2021-05-06)
The biological roles of DNA methylation have been elucidated by profiling methods based on whole-genome or reduced-representation bisulfite sequencing, but these approaches do not efficiently survey the vast numbers of ...