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The Protein Kinase KIS Impacts Gene Expression during Development and Fear Conditioning in Adult Mice
(Public Library of Science, 2012)
The brain-enriched protein kinase KIS (product of the gene UHMK1) has been shown to phosphorylate the human splicing factor SF1 in vitro. This phosphorylation in turn favors the formation of a \(U2AF^{65}\)-SF1-RNA complex ...
Role of Ca\(^{2+}\) in the Control of H\(_2\)O\(_2\)-Modulated Phosphorylation Pathways Leading to eNOS Activation in Cardiac Myocytes
(Public Library of Science, 2012)
Nitric oxide (NO) and hydrogen peroxide (H\(_2\)O\(_2\)) play key roles in physiological and pathological responses in cardiac myocytes. The mechanisms whereby H\(_2\)O\(_2\)–modulated phosphorylation pathways regulate the ...
Ca\(^{2+}\)/Calmodulin-Dependent Protein Kinase Kinase Is Not Involved in Hypothalamic AMP-Activated Protein Kinase Activation by Neuroglucopenia
(Public Library of Science, 2012)
Hypoglycemia and neuroglucopenia stimulate AMP-activated protein kinase (AMPK) activity in the hypothalamus and this plays an important role in the counterregulatory responses, i.e. increased food intake and secretion of ...
Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening
(Public Library of Science, 2012)
Background: Loss of function mutations in the DJ-1 gene have been linked to recessively inherited forms of Parkinsonism. Mitochondrial dysfunction and increased oxidative stress are thought to be key events in the pathogenesis ...
High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism
(Public Library of Science, 2012)
Identification of common molecular pathways affected by genetic variation in autism is important for understanding disease pathogenesis and devising effective therapies. Here, we test the hypothesis that rare genetic ...
Reduced Intestinal Tumorigenesis in APCmin Mice Lacking Melanin-Concentrating Hormone
(Public Library of Science, 2012)
Background: Melanin-concentrating hormone (MCH) is an evolutionary conserved hypothalamic neuropeptide that in mammals primarily regulates appetite and energy balance. We have recently identified a novel role for MCH in ...
Rhodopsin Expression Level Affects Rod Outer Segment Morphology and Photoresponse Kinetics
(Public Library of Science, 2012)
Background: The retinal rod outer segment is a sensory cilium that is specialized for the conversion of light into an electrical signal. Within the cilium, up to several thousand membranous disks contain as many as a billion ...
Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation
(Public Library of Science, 2012)
Anesthetic isoflurane has been shown to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of ...
A Glucose Fuel Cell for Implantable Brain–Machine Interfaces
(Public Library of Science, 2012)
We have developed an implantable fuel cell that generates power through glucose oxidation, producing 3.4 \(\mu\)W cm\(^{-2}\) steady-state power and up to 180 \(\mu\)W cm\(^{-2}\) peak power. The fuel cell is manufactured ...
Induction of Biogenic Magnetization and Redox Control by a Component of the Target of Rapamycin Complex 1 Signaling Pathway
(Public Library of Science, 2012)
Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial ...