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The Outer Pore and Selectivity Filter of TRPA1
(Public Library of Science, 2016)
TRPA1 (transient-receptor-potential-related ion channel with ankyrin domains) is a direct receptor or indirect effector for a wide variety of nociceptive signals, and thus is a compelling target for development of analgesic ...
Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3
(Public Library of Science, 2016)
Maresin conjugates in tissue regeneration (MCTR) are a new family of evolutionarily conserved chemical signals that orchestrate host responses to promote tissue regeneration and resolution of infections. Herein, we identified ...
Retroperitoneal Laparoscopic Management of Paraganglioma: A Single Institute Experience
(Public Library of Science, 2016)
Objectives: To explore the feasibility and safety of retroperitoneal laparoscopic resection of paraganglioma (RLPG) in a large study population. Methods: In a six-year period, 49 patients with primary retroperitoneal ...
Frontal Lobe Hemodynamic Responses to Painful Stimulation: A Potential Brain Marker of Nociception
(Public Library of Science, 2016)
The purpose of this study was to use functional near-infrared spectroscopy (fNIRS) to examine patterns of both activation and deactivation that occur in the frontal lobe in response to noxious stimuli. The frontal lobe was ...
Effect of Portal Glucose Sensing on Systemic Glucose Levels in SD and ZDF Rats
(Public Library of Science, 2016)
Background: The global epidemic of Type-2-Diabetes (T2D) highlights the need for novel therapeutic targets and agents. Roux-en-Y-Gastric-Bypass (RYGB) is the most effective treatment. Studies investigating the mechanisms ...
Learning Reward Uncertainty in the Basal Ganglia
(Public Library of Science, 2016)
Learning the reliability of different sources of rewards is critical for making optimal choices. However, despite the existence of detailed theory describing how the expected reward is learned in the basal ganglia, it is ...
Serum-Based Quantification of MYCN Gene Amplification in Young Patients with Neuroblastoma: Potential Utility as a Surrogate Biomarker for Neuroblastoma
(Public Library of Science, 2016)
We previously developed a method for determining MYCN gene amplification status using cell-free DNA fragments released from cancer cells into the blood of patients with neuroblastoma (NB). Here, we analyzed the relationship ...
Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse Neurons
(Public Library of Science, 2016)
Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, evidence for a specific neurotoxic effect on early synaptogenesis has not been demonstrated. Drebrin A is an actin binding ...
Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection
(Public Library of Science, 2016)
We have previously shown that transplantation of autologously derived, respiration-competent mitochondria by direct injection into the heart following transient ischemia and reperfusion enhances cell viability and contractile ...
An Uninformative Truth: The Logic of Amarin’s Off-Label Promotion
(Public Library of Science, 2016)
Spencer Phillips Hey and Aaron Kesselheim propose that informativeness—asserting scientific facts—rather than truthfulness ought to be the standard for regulating commercial speech about pharmaceuticals.