Browsing Harvard Medical School by Title
Now showing items 209-228 of 18442
-
ABO Blood Group and Incidence of Skin Cancer
(Public Library of Science, 2010)Background: Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and ... -
ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium
(Springer Science + Business Media, 2012)Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In 8 studies participating in the Ovarian Cancer Association Consortium ... -
Abolition of Cyclin-Dependent Kinase Inhibitor p16Ink4a and p21Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts
(American Society for Microbiology, 2003)Human cells are more resistant to both immortalization and malignant transformation than rodent cells. Recent studies have established the basic genetic requirements for the transformation of human cells, but much of this ... -
Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus
(Public Library of Science, 2013)Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and prevention ... -
Abrogation of Antibody-Induced Arthritis in Mice by a Self-Activating Viridin Prodrug and Association with Impaired Neutrophil and Endothelial Cell Function
(Wiley, 2009)Objective. To test a novel self-activating viridin (SAV) prodrug that slowly releases wortmannin, a potent phosphoinositide 3-kinase inhibitor, in a model of antibody-mediated inflammatory arthritis.Methods. The SAV prodrug ... -
Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice
(BioMed Central, 2007)Parkinson's disease is the most common movement disorder characterized by dopaminergic dysfunction and degeneration. Loss-of-function mutations in the DJ-1 gene have been linked to autosomal recessive forms of early-onset ... -
The Absence of Obstructive Sleep Apnea May Protect against Non-Alcoholic Fatty Liver in Patients Undergoing Bariatric Surgery
(Public Library of Science, 2013)Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide and its progressive form, steatohepatitis, will be the leading indication for liver transplant by 2020. While risk ... -
Absence of Replication of Porcine Endogenous Retrovirus and Porcine Lymphotropic Herpesvirus Type 1 with Prolonged Pig Cell Microchimerism after Pig-to-Baboon Xenotransplantation
(American Society for Microbiology, 2008)Porcine endogenous retrovirus (PERV), porcine cytomegalovirus (PCMV), and porcine lymphotropic her- pesvirus (PLHV) are common porcine viruses that may be activated with immunosuppression for xenotrans- plantation. Studies ... -
Absolute Enrichment: Gene Set Enrichment Analysis for Homeostatic Systems
(Oxford University Press, 2006)The Gene Set Enrichment Analysis (GSEA) identifies sets of genes that are differentially regulated in one direction. Many homeostatic systems will include one limb that is upregulated in response to a downregulation of ... -
Absolute quantification of somatic DNA alterations in human cancer
(2015)We developed a computational method (ABSOLUTE) that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. ABSOLUTE can detect subclonal heterogeneity, somatic homozygosity, and ... -
An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population
(Public Library of Science, 2013)Purpose We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. Patients and Methods Using data on 3,349 cases and 3,654 controls from the PanScan ... -
Absorbed Radiation Dose in Radiosensitive Organs Using 64- and 320-Row Multidetector Computed Tomography: A Comparative Study
(Hindawi Publishing Corporation, 2014)Aim. To determine absorbed radiation dose (ARD) in radiosensitive organs during prospective and full phase dose modulation using ECG-gated MDCTA scanner under 64- and 320-row detector modes. Methods:. Female phantom was ... -
Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers
(Impact Journals LLC, 2016)Gastric cancer (GC) is a deadly disease with limited treatment options. Recent studies with PD-1 inhibition have shown promising results in GC, but key questions remain regarding which GC subclass may respond best. In other ... -
AC and AG Dinucleotide Repeats in the PAX6 P1 Promoter are Associated with High Myopia
(Molecular Vision, 2009)Purpose: The PAX6 gene, located at the reported myopia locus MYP7 on chromosome 11p13, was postulated to be associated with myopia development. This study investigated the association of PAX6 with high myopia in 379 high ... -
Accelerated free breathing ECG triggered contrast enhanced pulmonary vein magnetic resonance angiography using compressed sensing
(BioMed Central, 2014)Background: To investigate the feasibility of accelerated electrocardiogram (ECG)-triggered contrast enhanced pulmonary vein magnetic resonance angiography (CE-PV MRA) with isotropic spatial resolution using compressed ... -
Accelerated Heterologous Prime-boost Adenovirus Vector-based SIV Vaccine in Neonatal Rhesus Monkeys
(BioMed Central, 2012) -
Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency
(AAI, 2016)Although common variable immunodeficiency (CVID) has long been considered as a group of primary Ab deficiencies, growing experimental data now suggest a global disruption of the entire adaptive immune response in a segment ... -
Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low–Birth Weight Mice
(American Diabetes Association, 2009)OBJECTIVE: To characterize the hormonal milieu and adipose gene expression in response to catch-up growth (CUG), a growth pattern associated with obesity and diabetes risk, in a mouse model of low birth weight (LBW). ... -
Accelerated three-dimensional free-breathing first pass cardiac perfusion at 1.5T
(BioMed Central, 2013) -
Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study
(Dove Medical Press, 2016)Objective: To examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve antiretroviral ...