Browsing Harvard Medical School by Keyword "expression"

Now showing items 1-5 of 5

    • Elevated HLA-A expression impairs HIV control through inhibition of Natural Killer cells 

      Ramsuran, Veron; Naranbhai, Vivek; Horowitz, Amir; Qi, Ying; Martin, Maureen; Yuki, Yuko; Gao, Xiaojiang; Fellay, Jacques; Deeks, Steven; Martin, Jeffrey N.; Goedert, James; Wolinsky, Steven; Michael, Nelson; Kirk, Gregory; Buchbinder, Susan; Haas, David; Ndung’u, Thumbi; Goulder, Philip; Parham, Peter; Walker, Bruce David; Carlson, Jonathan M.; Carrington, Mary
      The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects ...

    • Expression Dynamics of a Cellular Metabolic Network 

      Kharchenko, Peter Vasili; Church, George McDonald; Vitkup, Dennis (Nature Publishing Group, 2005)
      Toward the goal of understanding system properties of biological networks, we investigate the global and local regulation of gene expression in the Saccharomyces cerevisiae metabolic network. Our results demonstrate ...

    • Regulation of Neutrophils by Interferon-\(\gamma\) Limits Lung Inflammation During Tuberculosis Infection 

      Nandi, Bisweswar; Behar, Samuel M (The Rockefeller University Press, 2011)
      Resistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication while preventing an over-exuberant inflammatory response. Interferon (IFN) \(\gamma\) is crucial for activating macrophages and ...

    • Telomerase Inhibition by siRNA Causes Senescence and Apoptosis in Barrett's Adenocarcinoma Cells: Mechanism and Therapeutic Potential 

      Shammas, Masood A.; Koley, Hemanta; Batchu, Ramesh B.; Bertheau, Robert C.; Protopopov, Alexei; Munshi, Nikhil C; Goyal, Raj K. (BioMed Central, 2005)
      Background: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate ...

    • Unraveling the Transcriptional Network Controlling ES Cell Pluripotency 

      Rao, Sridhar; Orkin, Stuart Holland (BioMed Central, 2006)
      Embryonic stem cells (ES cells) are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate ...