Browsing HMS Scholarly Articles by Title

Now showing items 9890-9909 of 17928

    • Low-Dose Rectal Inoculation of Rhesus Macaques by SIVsmE660 or SIVmac251 Recapitulates Human Mucosal Infection by HIV-1 

      Keele, Brandon F.; Learn, Gerald H.; Hraber, Peter; Giorgi, Elena E.; Grayson, Truman; Sun, Chuanxi; Chen, Yalu; Mascola, John R.; Nabel, Gary J.; Haynes, Barton F.; Bhattacharya, Tanmoy; Perelson, Alan S.; Korber, Bette T.; Hahn, Beatrice H.; Shaw, George M.; Li, Hui; Yeh, Wendy Wen-Li; Letvin, Norman Lee (Rockefeller University Press, 2009)
      We recently developed a novel strategy to identify transmitted HIV-1 genomes in acutely infected humans using single-genome amplification and a model of random virus evolution. Here, we used this approach to determine the ...

    • Low-dose ultraviolet-B irradiation of donor corneal endothelium and graft survival 

      Dana, Reza; Olkowski, Steven; Ahmadian, Houshang; Stark, Walter J.; Young, Elaine M. (Association for Research in Vision and Ophthalmology, 1990)
      Donor rabbit corneal endothelium was pretreated with different doses of ultraviolet (UV-B) irradiation (302 nm) before grafting to test whether allograft survival could be favorably affected in comparison with untreated ...

    • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara M; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco; Hivert, Marie-France; Raghavan, Sridharan; Lipovich, Leonard; Hidalgo, Bertha; Fox, Keolu; Huffman, Jennifer E; An, Ping; Lu, Yingchang; Rasmussen-Torvik, Laura J; Grarup, Niels; Ehm, Margaret G; Li, Li; Baldridge, Abigail S; Stančáková, Alena; Abrol, Ravinder; Besse, Céline; Boland, Anne; Bork-Jensen, Jette; Fornage, Myriam; Freitag, Daniel F; Garcia, Melissa E; Guo, Xiuqing; Hara, Kazuo; Isaacs, Aaron; Jakobsdottir, Johanna; Lange, Leslie A; Layton, Jill C; Li, Man; Hua Zhao, Jing; Meidtner, Karina; Morrison, Alanna C; Nalls, Mike A; Peters, Marjolein J; Sabater-Lleal, Maria; Schurmann, Claudia; Silveira, Angela; Smith, Albert V; Southam, Lorraine; Stoiber, Marcus H; Strawbridge, Rona J; Taylor, Kent D; Varga, Tibor V; Allin, Kristine H; Amin, Najaf; Aponte, Jennifer L; Aung, Tin; Barbieri, Caterina; Bihlmeyer, Nathan A; Boehnke, Michael; Bombieri, Cristina; Bowden, Donald W; Burns, Sean M; Chen, Yuning; Chen, Yii-DerI; Cheng, Ching-Yu; Correa, Adolfo; Czajkowski, Jacek; Dehghan, Abbas; Ehret, Georg B; Eiriksdottir, Gudny; Escher, Stefan A; Farmaki, Aliki-Eleni; Frånberg, Mattias; Gambaro, Giovanni; Giulianini, Franco; Goddard, William A; Goel, Anuj; Gottesman, Omri; Grove, Megan L; Gustafsson, Stefan; Hai, Yang; Hallmans, Göran; Heo, Jiyoung; Hoffmann, Per; Ikram, Mohammad K; Jensen, Richard A; Jørgensen, Marit E; Jørgensen, Torben; Karaleftheri, Maria; Khor, Chiea C; Kirkpatrick, Andrea; Kraja, Aldi T; Kuusisto, Johanna; Lange, Ethan M; Lee, I T; Lee, Wen-Jane; Leong, Aaron; Liao, Jiemin; Liu, Chunyu; Liu, Yongmei; Lindgren, Cecilia M; Linneberg, Allan; Malerba, Giovanni; Mamakou, Vasiliki; Marouli, Eirini; Maruthur, Nisa M; Matchan, Angela; McKean-Cowdin, Roberta; McLeod, Olga; Metcalf, Ginger A; Mohlke, Karen L; Muzny, Donna M; Ntalla, Ioanna; Palmer, Nicholette D; Pasko, Dorota; Peter, Andreas; Rayner, Nigel W; Renström, Frida; Rice, Ken; Sala, Cinzia F; Sennblad, Bengt; Serafetinidis, Ioannis; Smith, Jennifer A; Soranzo, Nicole; Speliotes, Elizabeth K; Stahl, Eli A; Stirrups, Kathleen; Tentolouris, Nikos; Thanopoulou, Anastasia; Torres, Mina; Traglia, Michela; Tsafantakis, Emmanouil; Javad, Sundas; Yanek, Lisa R; Zengini, Eleni; Becker, Diane M; Bis, Joshua C; Brown, James B; Adrienne Cupples, L; Hansen, Torben; Ingelsson, Erik; Karter, Andrew J; Lorenzo, Carlos; Mathias, Rasika A; Norris, Jill M; Peloso, Gina M; Sheu, Wayne H.-H.; Toniolo, Daniela; Vaidya, Dhananjay; Varma, Rohit; Wagenknecht, Lynne E; Boeing, Heiner; Bottinger, Erwin P; Dedoussis, George; Deloukas, Panos; Ferrannini, Ele; Franco, Oscar H; Franks, Paul W; Gibbs, Richard A; Gudnason, Vilmundur; Hamsten, Anders; Harris, Tamara B; Hattersley, Andrew T; Hayward, Caroline; Hofman, Albert; Jansson, Jan-Håkan; Langenberg, Claudia; Launer, Lenore J; Levy, Daniel; Oostra, Ben A; O'Donnell, Christopher J; O'Rahilly, Stephen; Padmanabhan, Sandosh; Pankow, James S; Polasek, Ozren; Province, Michael A; Rich, Stephen S; Ridker, Paul M; Rudan, Igor; Schulze, Matthias B; Smith, Blair H; Uitterlinden, André G; Walker, Mark; Watkins, Hugh; Wong, Tien Y; Zeggini, Eleftheria; Sharp, Stephen J; Forouhi, Nita G; Kerrison, Nicola D; Lucarelli, Debora ME; Sims, Matt; Barroso, Inês; McCarthy, Mark I; Arriola, Larraitz; Balkau, Beverley; Barricarte, Aurelio; Gonzalez, Carlos; Grioni, Sara; Kaaks, Rudolf; Key, Timothy J; Navarro, Carmen; Nilsson, Peter M; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Quirós, J. Ramón; Rolandsson, Olov; Sacerdote, Carlotta; Sánchez, María–José; Slimani, Nadia; Tjonneland, Anne; Tumino, Rosario; van der A, Daphne L; van der Schouw, Yvonne T; Riboli, Elio; Laakso, Markku; Borecki, Ingrid B; Chasman, Daniel I; Pedersen, Oluf; Psaty, Bruce M; Shyong Tai, E; van Duijn, Cornelia M; Wareham, Nicholas J; Waterworth, Dawn M; Boerwinkle, Eric; Linda Kao, W H; Florez, Jose C; Loos, Ruth J.F.; Wilson, James G; Frayling, Timothy M; Siscovick, David S; Dupuis, Josée; Rotter, Jerome I; Meigs, James B; Scott, Robert A; Goodarzi, Mark O (Nature Pub. Group, 2015)
      Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...

    • Low-level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis 

      Lanphear, Bruce P.; Hornung, Richard; Khoury, Jane; Yolton, Kimberly; Baghurst, Peter; Canfield, Richard L.; Dietrich, Kim N.; Bornschein, Robert; Greene, Tom; Needleman, Herbert L.; Schnaas, Lourdes; Wasserman, Gail; Graziano, Joseph; Roberts, Russell; Bellinger, David C.; Rothenberg, Stephen J. (National Institue of Environmental Health Sciences, 2005)
      Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 μg/dL and whether lower exposures are, for a given change in exposure, associated with greater ...

    • Low-Level Expression and Reversion both Contribute to Reactivation of Herpes Simplex Virus Drug-Resistant Mutants with Mutations on Homopolymeric Sequences in Thymidine Kinase 

      Griffiths, Anthony; Link, Malen A.; Furness, Caroline L.; Coen, Donald M. (American Society for Microbiology, 2006)
      Many acyclovir-resistant herpes simplex virus isolates from patients contain insertions or deletions in homopolymeric sequences in the thymidine kinase (TK) gene (tk). Viruses that have one (G8) or two (G9) base insertions ...

    • Low-level laser therapy for spinal cord injury in rats: effects of polarization 

      Ando, Takahiro; Sato, Shunichi; Kobayashi, Hiroaki; Nawashiro, Hiroshi; Ashida, Hiroshi; Hamblin, Michael R.; Obara, Minoru (Society of Photo-Optical Instrumentation Engineers, 2013)
      Abstract. The effects of laser polarization on the efficacy of near-infrared low-level laser therapy for spinal cord injury (SCI) are presented. Rat spinal cords were injured with a weight-drop device, and the lesion sites ...

    • Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study 

      Park, Sung Kyun; Schwartz, Joel David; Weisskopf, Marc G.; Sparrow, David; Vokonas, Pantel S; Wright, Robert O.; Coull, Brent Andrew; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2006)
      Background: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. Objective: We examined the association of low-level lead ...

    • Low-level light in combination with metabolic modulators for effective therapy of injured brain 

      Dong, Tingting; Zhang, Qi; Hamblin, Michael; Wu, Mel (Nature Publishing Group, 2015)
      Stem cell technology has facilitated the development of human cell culture models of disease that can be used to study pathogenesis and test therapeutic candidates. These models hold particular promise for complex neurological ...

    • Low-level light treatment ameliorates immune thrombocytopenia 

      Yang, Jingke; Zhang, Qi; Li, Peiyu; Dong, Tingting; Wu, Mei X. (Nature Publishing Group, 2016)
      Immune thrombocytopenia (ITP) is an immune-mediated acquired bleeding disorder characterized by abnormally low platelet counts. We reported here the ability of low-level light treatment (LLLT) to alleviate ITP in mice. The ...

    • Low-Molecular Weight Heparin Increases Circulating sFlt-1 Levels and Enhances Urinary Elimination 

      Hagmann, Henning; Bossung, Verena; Belaidi, Abdel Ali; Fridman, Alexander; Karumanchi, S. Ananth; Thadhani, Ravi; Schermer, Bernhard; Mallmann, Peter; Schwarz, Guenter; Benzing, Thomas; Brinkkoetter, Paul T. (Public Library of Science, 2014)
      Rationale: Preeclampsia is a devastating medical complication of pregnancy which leads to maternal and fetal morbidity and mortality. While the etiology of preeclampsia is unclear, human and animal studies suggest that ...

    • Low-volume, high-throughput sandwich immunoassays for profiling plasma proteins in mice: identification of early-stage systemic inflammation in a mouse model of intestinal cancer 

      Forrester, Sara; Hung, Kenneth E.; Kuick, Rork; Kucherlapati, Raju; Haab, Brian B. (Wiley Open Access, 2007)
      Mouse models of human cancers may provide a valuable resource for the discovery of cancer biomarkers. We have developed a practical strategy for profiling specific proteins in mouse plasma using low-volume sandwich-immunoassays. ...

    • Lower Conjunctival Fornix Packing for Mydriasis in Premature Infants: A Randomized Trial 

      Thanathanee, Onsiri; Ratanapakorn, Tanapat; Morley, Michael Gerard; Yospaiboon, Yosanan (Dove Medical Press, 2012)
      Objective: To compare the mydriatic effect of lower conjunctival fornix packing to conventional instillation of eyedrops containing 2.5% phenylephrine and 1% tropicamide in premature infants undergoing examination for ...

    • Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage 

      Esposito, Elga; Mandeville, Emiri T; Lo, Eng H (BioMed Central, 2013)
      Background: Intracerebral hemorrhage is a subtype of stroke that has a poor prognosis without an adequate therapy. Recently, the use of anesthetics such as isoflurane has been shown to be protective after cerebral ischemia. ...

    • Lower Expression of Genes near microRNA in C. elegans Germline 

      Inaoka, Hidenori; Fukuoka, Yutaka; Kohane, Isaac Samuel (BioMed Central, 2006)
      Background: MicroRNAs (miRNAs) are recently discovered short non-protein-coding RNA molecules. miRNAs are increasingly implicated in tissue-specific transcriptional control and particularly in development. Because there ...

    • Lower Ghrelin Levels Are Associated With Higher Anxiety Symptoms in Adolescents and Young Adults With Avoidant/Restrictive Food Intake Disorder 

      Chovel Sella, Aluma; Hadaway, Natalia; Stern, Casey; Becker, Kendra R.; Holsen, Laura M.; Eddy, Kamryn T.; Micali, Nadia; Misra, Madhusmita; Thomas, Jennifer J.; Lawson, Elizabeth A. (Physicians Postgraduate Press, Inc, 2023-05-03)
      Objective: Avoidant/restrictive food intake disorder (ARFID) is associated with increased risk for anxiety, which may adversely affect prognosis. The appetite-stimulating hormone, ghrelin, increases in response to stress, ...

    • Lower Left Temporal Lobe MRI Volumes in Patients With First-Episode Schizophrenia Compared With Psychotic Patients With First-Episode Affective Disorder and Normal Subjects 

      Hirayasu, Yoshio; Shenton, Martha Elizabeth; Salisbury, Dean F.; Dickey, Chandlee C.; Fischer, Iris A.; Mazzoni, Paola; Kisler, Tanya; Arakaki, Hajime; Kwon, Jun Soo; Anderson, Jane E.; Yurgelun-Todd, Deborah; Tohen, Mauricio; McCarley, Robert William (American Psychiatric Publishing, 1998)
      Objective:Magnetic resonance imaging (MRI) studies of schizophrenic patients have revealed structural brain abnormalities, with low volumes of gray matter in the left posterior superior temporal gyrus and in medial temporal ...

    • Lower Left Thalamic Myo-Inositol Levels Associated with Greater Cognitive Impulsivity in Marijuana-Dependent Young Men: Preliminary Spectroscopic Evidence at 4T 

      Mashhoon, Yasmin; Jensen, J Eric; Sneider, Jennifer T; Yurgelun-Todd, Deborah A; Silveri, Marisa M (2013)
      The effects of chronic marijuana (MRJ) use on neurochemistry are not well characterized. Previously, altered global myo-Inositol (mI) concentrations and distribution in white matter were associated with impulsivity and ...

    • Lower Pill Burden and Once-Daily Antiretroviral Treatment Regimens for HIV Infection: A Meta-Analysis of Randomized Controlled Trials 

      Nachega, Jean B.; Parienti, Jean-Jacques; Uthman, Olalekan A.; Gross, Robert; Dowdy, David W.; Sax, Paul E.; Gallant, Joel E.; Mugavero, Michael J.; Mills, Edward J.; Giordano, Thomas P. (Oxford University Press, 2014)
      Background. Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) ...

    • Lower Use of Hospice by Cancer Patients who Live in Minority Versus White Areas 

      Earle, Craig C.; Orav, John E.; Brawarsky, Phyllis; Neville, Bridget A.; Haas, Jennifer S.; Acevedo Garcia, Dolores; Williams, David R. (Springer-Verlag, 2007)
      Background: Although hospice care can alleviate suffering at the end of life for patients with cancer, it remains underutilized, particularly by African Americans and Hispanics. Objective: To examine whether the racial ...

    • Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02 

      Leitman, Ellen M.; Hurst, Jacob; Mori, Masahiko; Kublin, James; Ndung'u, Thumbi; Walker, Bruce D.; Carlson, Jonathan; Gray, Glenda E.; Matthews, Philippa C.; Frahm, Nicole; Goulder, Philip J.R. (Oxford University Press, 2016)
      Background. HLA strongly influences human immunodeficiency virus type 1 (HIV-1) disease progression. A major contributory mechanism is via the particular HLA-presented HIV-1 epitopes that are recognized by CD8+ T-cells. ...