Browsing by Author "Hooker, Jacob"
Now showing items 21-40 of 54
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Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [ 11 C]MS-275 using Positron Emission Tomography
Hooker, Jacob M; Kim, Sung Won; Alexoff, David; Xu, Youwen; Shea, Colleen; Reid, Alicia; Volkow, Nora; Fowler, Joanna S. (American Chemical Society (ACS), 2010)MS-275 (entinostat) is a histone deacetylase (HDAC) inhibitor currently in clinical trials for the treatment of several types of cancer. Recent reports have noted that MS-275 can cross the blood−brain barrier (BBB) and ... -
Imaging Evaluation of 5HT\(_{2C}\) Agonists, [\(^{11}\)C]WAY-163909 and [\(^{11}\)C]Vabicaserin, Formed by Pictet–Spengler Cyclization
Neelamegam, Ramesh; Hellenbrand, Tim; Schroeder, Frederick A; Wang, Changning; Hooker, Jacob M (American Chemical Society (ACS), 2014)The serotonin subtype 2C (5HT\(_{2C}\)) receptor is an emerging and promising drug target to treat several disorders of the human central nervous system. In this current report, two potent and selective 5HT\(_{2C}\) full ... -
Improved PET Data Quantification in Simultaneous PET/MR Neuroimaging
Chonde, Daniel B. (2015-05-16)Recently, systems that integrate positron emission tomography and magnetic resonance imaging (PET/MR) have become available for clinical use. This new technology, which combines the high spatial resolution and superior ... -
In Vivo Imaging of Adult Human Hippocampal Neurogenesis: Progress, Pitfalls and Promise
Ho, N F; Hooker, Jacob M; Sahay, Amar; Holt, Daphne Jane; Roffman, Joshua Lawrence (Springer Nature, 2013)New neurons are produced within the hippocampus of the mammalian brain throughout life. Evidence from animal studies has suggested that the function of these adult-born neurons is linked to cognition and emotion. Until we ... -
In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs
Wang, Changning; Schroeder, Frederick A.; Wey, Hsiao-Ying; Borra, Ronald; Wagner, Florence F.; Reis, Surya; Kim, Sung Won; Holson, Edward B.; Haggarty, Stephen J.; Hooker, Jacob M. (American Chemical Society, 2014)Epigenetic enzymes are now targeted to treat the underlying gene expression dysregulation that contribute to disease pathogenesis. Histone deacetylases (HDACs) have shown broad potential in treatments against cancer and ... -
In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light
Ran, Chongzhao; Zhang, Zhaoda; Hooker, Jacob M; Moore, Anna V. (Springer Nature, 2011)Purpose: The poor tissue penetration of visible light has been a major barrier for optical imaging, photoactivatable conversions, and photodynamic therapy for in vivo targets with depths beyond 10 mm. In this report, as a ... -
Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28
Zürcher, Nicole R.; Loggia, Marco L.; Lawson, Robert; Chonde, Daniel B.; Izquierdo-Garcia, David; Yasek, Julia E.; Akeju, Oluwaseun; Catana, Ciprian; Rosen, Bruce R.; Cudkowicz, Merit E.; Hooker, Jacob M.; Atassi, Nazem (Elsevier, 2015)Evidence from human post mortem, in vivo and animal model studies implicates the neuroimmune system and activated microglia in the pathology of amyotrophic lateral sclerosis. The study aim was to further evaluate in vivo ... -
Metabolic Changes in the Rodent Brain after Acute Administration of Salvinorin A
Hooker, Jacob M; Patel, Vinal; Kothari, Shiva; Schiffer, Wynne K. (Springer Nature, 2009)Purpose: Salvinorin A (SA) is a potent and highly selective kappa-opioid receptor (KOR) agonist with rapid kinetics and commensurate behavioral effects; however, brain regions associated with these effects have not been ... -
Modular Strategies for PET Imaging Agents
Hooker, Jacob M (Elsevier BV, 2010)In recent years, modular and simplified chemical and biological strategies have been developed for the synthesis and implementation of positron emission tomography (PET) radiotracers. New developments in bioconjugation and ... -
Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI
Sander, C. Y.; Hooker, Jacob M; Catana, Ciprian; Normandin, Marc D; Alpert, Nathaniel Moritz; Knudsen, G. M.; Vanduffel, Wim J.M.; Rosen, Bruce; Mandeville, Joseph B. (Proceedings of the National Academy of Sciences, 2013)This study employed simultaneous neuroimaging with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between changes in receptor occupancy measured by PET ... -
Nickel-Mediated Oxidative Fluorination for PET with Aqueous [\(^{18}F\)] Fluoride
Lee, Eunsung; Hooker, Jacob M; Ritter, Tobias (American Chemical Society, 2012)A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical \(^{18}F\) late-stage ... -
Nicotine Blocks Brain Estrogen Synthase (Aromatase): In Vivo Positron Emission Tomography Studies in Female Baboons
Biegon, Anat; Kim, Sung-Won; Logan, Jean; Hooker, Jacob M; Muench, Lisa; Fowler, Joanna S. (Elsevier BV, 2010)The front-line tuberculosis (TB) chemotherapeutics isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA) have been labeled with carbon-11 and the biodistribution of each labeled drug has been determined in baboons using ... -
Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma1
Kumar, Vidhya; Boucher, Yves; Liu, Hao; Ferreira, Diego; Hooker, Jacob; Catana, Ciprian; Hoover, Andrew J.; Ritter, Tobias; Jain, Rakesh K.; Guimaraes, Alexander R. (Neoplasia Press, 2016)PURPOSE: Losartan, an angiotensin II receptor blocker, can reduce desmoplasia and enhance drug delivery and efficacy through improving interstitial transport and vascular perfusion in pancreatic ductal adenocarcinoma (PDAC) ... -
Noninvasive Determination of 2-[18F]-Fluoroisonicotinic Acid Hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis-Infected Mice
Weinstein, E. A.; Liu, L.; Ordonez, A. A.; Wang, H.; Hooker, Jacob M; Tonge, P. J.; Jain, S. K. (American Society for Microbiology, 2012)Tuberculosis (TB) is a global pandemic requiring sustained therapy to facilitate curing and to prevent the emergence of drug resistance. There are few adequate tools to evaluate drug dynamics within infected tissues in ... -
One-Pot, Direct Incorporation of [11 C]CO 2 into Carbamates
Hooker, Jacob M; Reibel, Achim T.; Hill, Sidney M.; Schueller, Michael J.; Fowler, Joanna S. (Wiley-Blackwell, 2009)Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75 °C ... -
PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates
Rotstein, Benjamin H.; Wey, Hsiao-Ying; Shoup, Timothy M.; Wilson, Alan A.; Liang, Steven H.; Hooker, Jacob M.; Vasdev, Neil (American Chemical Society, 2014)Fatty acid amide hydrolase (FAAH) regulates endocannabinoid signaling. [11C]CURB, an irreversibly binding FAAH inhibitor, has been developed for clinical research imaging with PET. However, no fluorine-18 labeled radiotracer ... -
Pharmacokinetics of the Potent Hallucinogen, Salvinorin A in Primates Parallels the Rapid Onset and Short Duration of Effects in Humans
Hooker, Jacob M; Xu, Youwen; Schiffer, Wynne; Shea, Colleen; Carter, Pauline; Fowler, Joanna S. (Elsevier BV, 2008)Salvia divinorum, a mint plant originally used by the Mazatecs of Oaxaca, Mexico in spiritual rituals has gained popularity, in smoked form, as a legal hallucinogen in the United States and Europe. Abuse results in rapid ... -
A Philosophy for CNS Radiotracer Design
Van de Bittner, Genevieve C.; Ricq, Emily L.; Hooker, Jacob M. (American Chemical Society, 2014)Conspectus Decades after its discovery, positron emission tomography (PET) remains the premier tool for imaging neurochemistry in living humans. Technological improvements in radiolabeling methods, camera design, and image ... -
Radionuclide Labeling and Evaluation of Candidate Radioligands for PET Imaging of Histone Deacetylase in the Brain
Seo, Young Ah; Muench, Lisa; Reid, Alicia; Chen, Jinzhu; Kang, Yeona; Hooker, Jacob M; Volkow, Nora D.; Fowler, Joanna S.; Kim, Sung Won (Elsevier BV, 2013)Histone deacetylases (HDACs) regulate gene expression by inducing conformational changes in chromatin. Ever since the discovery of a naturally occurring HDAC inhibitor, trichostatin A (TSA) stimulated the recent development ... -
Radiosynthesis and Bioimaging of the Tuberculosis Chemotherapeutics Isoniazid, Rifampicin and Pyrazinamide in Baboons
Liu, Li; Xu, Youwen; Shea, Colleen; Fowler, Joanna S.; Hooker, Jacob M; Tonge, Peter J. (American Chemical Society (ACS), 2010)The front-line tuberculosis (TB) chemotherapeutics isoniazid (INH), rifampicin (RIF), and pyrazinamide (PZA) have been labeled with carbon-11 and the biodistribution of each labeled drug has been determined in baboons using ...