One-Pot, Direct Incorporation of [11 C]CO 2 into Carbamates
View/ Open
Hooker_OnePot.pdf (322.8Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Published Version
https://doi.org/10.1002/anie.200900112Metadata
Show full item recordCitation
Hooker, Jacob M., Achim T. Reibel, Sidney M. Hill, Michael J. Schueller, and Joanna S. Fowler. 2009. “One-Pot, Direct Incorporation of [11C]CO2into Carbamates.” Angewandte Chemie International Edition 48 (19) (April 27): 3482–3485. doi:10.1002/anie.200900112.Abstract
Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75 °C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:33471157
Collections
- HMS Scholarly Articles [17714]
Contact administrator regarding this item (to report mistakes or request changes)