dc.contributor.author | Zhang, Jiangwen | en_US |
dc.contributor.author | Jackson, Audrey F. | en_US |
dc.contributor.author | Naito, Taku | en_US |
dc.contributor.author | Dose, Marei | en_US |
dc.contributor.author | Seavitt, John | en_US |
dc.contributor.author | Liu, Feifei | en_US |
dc.contributor.author | Heller, Elizabeth J. | en_US |
dc.contributor.author | Kashiwagi, Mariko | en_US |
dc.contributor.author | Yoshida, Toshimi | en_US |
dc.contributor.author | Gounari, Fotini | en_US |
dc.contributor.author | Petrie, Howard T. | en_US |
dc.contributor.author | Georgopoulos, Katia | en_US |
dc.date.accessioned | 2014-03-11T10:17:30Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Zhang, J., A. F. Jackson, T. Naito, M. Dose, J. Seavitt, F. Liu, E. J. Heller, et al. 2013. “Harnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis.” Nature immunology 13 (1): 10.1038/ni.2150. doi:10.1038/ni.2150. http://dx.doi.org/10.1038/ni.2150. | en |
dc.identifier.issn | 1529-2908 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879386 | |
dc.description.abstract | Cell fate decisions depend on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2β nucleosome remodeling and deacetylase (NuRD) complex was controlled by the Ikaros family of lymphoid-lineage determining proteins. Ikaros, an integral component of the NuRD complex in lymphocytes, tethered this complex to active lymphoid differentiation genes. Loss in Ikaros DNA binding activity caused a local increase in Mi-2β chromatin remodeling and histone deacetylation and suppression of lymphoid gene expression. The NuRD complex also redistributed to transcriptionally poised non-Ikaros gene targets, involved in proliferation and metabolism, inducing their reactivation. Thus, release of NuRD from Ikaros regulation blocks lymphocyte maturation and mediates progression to a leukemic state by engaging functionally opposing epigenetic and genetic networks. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/ni.2150 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868219/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Harnessing of the Nucleosome Remodeling Deacetylase complex controls lymphocyte development and prevents leukemogenesis | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature immunology | en |
dash.depositing.author | Seavitt, John | en_US |
dc.date.available | 2014-03-11T10:17:30Z | |
dc.identifier.doi | 10.1038/ni.2150 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Kashiwagi, Mariko | |
dash.contributor.affiliated | Seavitt, John | |
dash.contributor.affiliated | Yoshida, Toshimi | |
dash.contributor.affiliated | Georgopoulos, Katia | |