11CO2 Fixation: A Renaissance in PET Radiochemistry
Wilson, Alan A.
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CitationRotstein, Benjamin H., Steven H. Liang, Jason P. Holland, Thomas Lee Collier, Jacob M. Hooker, Alan A. Wilson, and Neil Vasdev. 2013. 11CO2 fixation: a renaissance in PET radiochemistry. Chemical Communications 49(50): 5621.
AbstractCarbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [11C]CO2. In recent years, [11C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [11C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [11C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.
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