11CO2 Fixation: A Renaissance in PET Radiochemistry

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11CO2 Fixation: A Renaissance in PET Radiochemistry

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Title: 11CO2 Fixation: A Renaissance in PET Radiochemistry
Author: Rotstein, Benjamin H; Liang, Steven; Holland, Jason P; Collier, Thomas L; Hooker, Jacob M; Wilson, Alan A.; Vasdev, Neil

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Citation: Rotstein, Benjamin H., Steven H. Liang, Jason P. Holland, Thomas Lee Collier, Jacob M. Hooker, Alan A. Wilson, and Neil Vasdev. 2013. 11CO2 fixation: a renaissance in PET radiochemistry. Chemical Communications 49(50): 5621.
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Abstract: Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [11C]CO2. In recent years, [11C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [11C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [11C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.
Published Version: doi:10.1039/c3cc42236d
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12111436
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