Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study
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Author
Sartelli, Massimo
Catena, Fausto
Ansaloni, Luca
Coccolini, Federico
Corbella, Davide
Moore, Ernest E
Malangoni, Mark
Coimbra, Raul
Koike, Kaoru
Leppaniemi, Ari
Biffl, Walter
Balogh, Zsolt
Bendinelli, Cino
Gupta, Sanjay
Kluger, Yoram
Agresta, Ferdinando
Saverio, Salomone Di
Tugnoli, Gregorio
Jovine, Elio
Ordonez, Carlos A
Whelan, James F
Fraga, Gustavo P
Gomes, Carlos Augusto
Pereira, Gerson Alves
Yuan, Kuo-Ching
Bala, Miklosh
Peev, Miroslav P
Ben-Ishay, Offir
Cui, Yunfeng
Marwah, Sanjay
Zachariah, Sanoop
Wani, Imtiaz
Rangarajan, Muthukumaran
Sakakushev, Boris
Kong, Victor
Ahmed, Adamu
Abbas, Ashraf
Gonsaga, Ricardo Alessandro Teixeira
Guercioni, Gianluca
Vettoretto, Nereo
Poiasina, Elia
Díaz-Nieto, Rafael
Massalou, Damien
Skrovina, Matej
Gerych, Ihor
Augustin, Goran
Kenig, Jakub
Khokha, Vladimir
Tranà, Cristian
Kok, Kenneth Yuh Yen
Mefire, Alain Chichom
Lee, Jae Gil
Hong, Suk-Kyung
Lohse, Helmut Alfredo Segovia
Ghnnam, Wagih
Verni, Alfredo
Lohsiriwat, Varut
Siribumrungwong, Boonying
El Zalabany, Tamer
Tavares, Alberto
Baiocchi, Gianluca
Das, Koray
Jarry, Julien
Zida, Maurice
Sato, Norio
Murata, Kiyoshi
Shoko, Tomohisa
Irahara, Takayuki
Hamedelneel, Ahmed O
Naidoo, Noel
Adesunkanmi, Abdul Rashid Kayode
Kobe, Yoshiro
Ishii, Wataru
Oka, Kazuyuki
Izawa, Yoshimitsu
Hamid, Hytham
Khan, Iqbal
Attri, AK
Sharma, Rajeev
Sanjuan, Juan
Badiel, Marisol
Barnabé, Rita
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1186/1749-7922-9-37Metadata
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Sartelli, M., F. Catena, L. Ansaloni, F. Coccolini, D. Corbella, E. E. Moore, M. Malangoni, et al. 2014. “Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study.” World Journal of Emergency Surgery : WJES 9 (1): 37. doi:10.1186/1749-7922-9-37. http://dx.doi.org/10.1186/1749-7922-9-37.Abstract
The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039043/pdf/Terms of Use
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