Identification of a Selective Small Molecule Inhibitor of Breast Cancer Stem Cells

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Identification of a Selective Small Molecule Inhibitor of Breast Cancer Stem Cells

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Title: Identification of a Selective Small Molecule Inhibitor of Breast Cancer Stem Cells
Author: Germain, Andrew R.; Carmody, Leigh C.; Morgan, Barbara; Fernandez, Cristina; Forbeck, Erin; Lewis, Timothy A.; Nag, Partha P.; Ting, Amal; VerPlank, Lynn; Feng, Yuxiong; Perez, Jose R.; Dandapani, Sivaraman; Palmer, Michelle; Lander, Eric Steven; Gupta, Piyush B.; Schreiber, Stuart L.; Munoz, Benito

Note: Order does not necessarily reflect citation order of authors.

Citation: Germain, Andrew R., Leigh C. Carmody, Barbara Morgan, Cristina Fernandez, Erin Forbeck, Timothy A. Lewis, Partha P. Nag, et al. 2012. “Identification of a Selective Small Molecule Inhibitor of Breast Cancer Stem Cells.” Bioorganic & Medicinal Chemistry Letters 22 (10) (May): 3571–3574. doi:10.1016/j.bmcl.2012.01.035. http://dx.doi.org/10.1016/j.bmcl.2012.01.035.
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Abstract: A high-throughput screen (HTS) with the National Institute of Health–Molecular Libraries Small Molecule Repository (NIH–MLSMR) compound collection identified a class of acyl hydrazones to be selectively lethal to breast cancer stem cell (CSC) enriched populations. Medicinal chemistry efforts were undertaken to optimize potency and selectivity of this class of compounds. The optimized compound was declared as a probe (ML239) with the NIH Molecular Libraries Program and displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control line (HMLE_sh_GFP).
Published Version: doi:10.1016/j.bmcl.2012.01.035
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/22503247
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12719983
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