Germain, Andrew R., Leigh C. Carmody, Barbara Morgan, Cristina Fernandez, Erin Forbeck, Timothy A. Lewis, Partha P. Nag, et al. 2012. “Identification of a Selective Small Molecule Inhibitor of Breast Cancer Stem Cells.” Bioorganic & Medicinal Chemistry Letters 22 (10) (May): 3571–3574. doi:10.1016/j.bmcl.2012.01.035. http://dx.doi.org/10.1016/j.bmcl.2012.01.035.
A high-throughput screen (HTS) with the National Institute of Health–Molecular Libraries Small Molecule Repository (NIH–MLSMR) compound collection identified a class of acyl hydrazones to be selectively lethal to breast cancer stem cell (CSC) enriched populations. Medicinal chemistry efforts were undertaken to optimize potency and selectivity of this class of compounds. The optimized compound was declared as a probe (ML239) with the NIH Molecular Libraries Program and displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control line (HMLE_sh_GFP).
Schreiber's assistant called to push this into DASH quickly (8/8/14); file is corrupt so emailed assistant for a new version (8/8/14); emailed 8/14/14 to see if assistant has access to final manuscript version, or whether should go in dark; new files received still have Elsevier headers on them, will deposit dark