A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach

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A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach

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Title: A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach
Author: Lucia, Umberto; Ponzetto, Antonio; Deisboeck, Thomas S.

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Citation: Lucia, Umberto, Antonio Ponzetto, and Thomas S. Deisboeck. 2014. “A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach.” Scientific Reports 4 (1): 6763. doi:10.1038/srep06763. http://dx.doi.org/10.1038/srep06763.
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Abstract: Pumping protons across a membrane was a critical step at the origin of life on earth, and it is still performed in all living organisms, including in human cells. Proton pumping is paramount to keep normal cells alive, e.g. for lysosomal digestion and for preparing peptides for immune recognition, but it goes awry in cancer cells. They acidify their microenvironment hence membrane voltage is lowered, which in turn induces cell proliferation, a hallmark of cancer. Proton pumping is achieved by means of rotary motors, namely vacuolar ATPases (V-ATPase), which are present at many of the multiple cellular interfaces. Therefore, we undertook an examination of the thermodynamic properties of V-ATPases. The principal result is that the V-ATPase-mediated control of the cell membrane potential and the related and consequent environmental pH can potentially represent a valuable support strategy for anticancer therapies. A constructal theory approach is used as a new viewpoint to study how V-ATPase can be modulated for therapeutic purposes. In particular, V-ATPase can be regulated by using external fields, such as electromagnetic fields, and a theoretical approach has been introduced to quantify the appropriate field strength and frequency for this new adjuvant therapeutic strategy.
Published Version: doi:10.1038/srep06763
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208057/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347594
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