Browsing FAS Scholarly Articles by Author "Keskula, Paula"

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    • Integrated genetic and pharmacologic interrogation of rare cancers 

      Hong, Andrew L.; Tseng, Yuen-Yi; Cowley, Glenn S.; Jonas, Oliver; Cheah, Jaime H.; Kynnap, Bryan D.; Doshi, Mihir B.; Oh, Coyin; Meyer, Stephanie C.; Church, Alanna J.; Gill, Shubhroz; Bielski, Craig M.; Keskula, Paula; Imamovic, Alma; Howell, Sara; Kryukov, Gregory V.; Clemons, Paul A.; Tsherniak, Aviad; Vazquez, Francisca; Crompton, Brian D.; Shamji, Alykhan F.; Rodriguez-Galindo, Carlos; Janeway, Katherine A.; Roberts, Charles W. M.; Stegmaier, Kimberly; van Hummelen, Paul; Cima, Michael J.; Langer, Robert S.; Garraway, Levi A.; Schreiber, Stuart L.; Root, David E.; Hahn, William C.; Boehm, Jesse S. (Nature Publishing Group, 2016)
      Identifying therapeutic targets in rare cancers remains challenging due to the paucity of established models to perform preclinical studies. As a proof-of-concept, we developed a patient-derived cancer cell line, CLF-PED-015-T, ...

    • The Landscape of Cancer Cell Line Metabolism 

      Li, Haoxin; Ning, Shaoyang; Gopal, Shuba; Deik, Amy; Souza, Amanda; Pierce, Kerry; Keskula, Paula; Hernandez, Desiree; Ann, Julie; Shkoza, Dojna; Apfel, Verena; Zou, Yilong; Vazquez, Francisca; Barretina, Jordi; Tsherniak, Aviad; Giannakis, Marios; Ghandi, Mahmoud; Kryukov, Gregory; Pagliarini, Raymond; Galli, Giorgio; Root, David; Hahn, William; Schreiber, Stuart; Clish, Clary; Garraway, Levi; Sellers, William (Springer Science and Business Media LLC, 2019-05)
      Despite considerable efforts to identify cancer metabolic alterations that might unveil druggable vulnerabilities, systematic characterizations of metabolism as it relates to functional genomic features and associated ...