Browsing FAS Scholarly Articles by Author "Cotton, Jennifer"
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Gli Transcriptional Activity Is Essential for Kras-Induced Pancreatic Tumorigenesis and Regulates IKBKE/NF-\(\kappa\)B Activity in the Tumor Epithelium
Rajurkar, Mihir; de Jesus-Monge, Wilfredo E.; Driscoll, David R.; Appleman, Victoria A.; Huang, He; Cotton, Jennifer; Klimstra, David; Zhu, Lihua; Simin, Karl; Xu, Lan; McMahon, Andrew P.; Lewis, Brian; Mao, Junhao (National Academy of Science, 2012)Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive human malignances, is thought to be initiated by KRAS activation. Here we find that transcriptional activation mediated by the Gli family of transcription ...