Browsing FAS Scholarly Articles by Author "Chen, Jonathan"

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    • Engineered pegRNAs improve prime editing efficiency 

      Nelson, James W.; Randolph, Peyton B.; Shen, Simon; Everette, Kelcee A.; Chen, Peter; Anzalone, Andrew; An, Meirui; Newby, Gregory; Chen, Jonathan; Hsu, Alvin; Liu, David (Springer Science and Business Media LLC, 2021-10-04)
      Prime editing enables the installation of virtually any combination of point mutations, small insertions or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) directs the prime editor protein ...