Browsing FAS Scholarly Articles by Author "Cottini, Francesca"

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    • Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma 

      Hideshima, Teru; Qi, Jun; Paranal, Ronald; Tang, Weiping; Greenberg, Edward; West, Nathan; Colling, Meaghan; Estiu, Guillermina; Mazitschek, Ralph; Perry, Jennifer; Ohguchi, Hiroto; Cottini, Francesca; Mimura, Naoya; Güllü Görgün; Tai, Yu-Tzu; Richardson, Paul; Carrasco, Ruben; Wiest, Olaf; Schreiber, Stuart; Anderson, Kenneth; Bradner, James (National Academy of Sciences, 2016)
      Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib ...