Browsing FAS Scholarly Articles by Title

Now showing items 3789-3808 of 18292

    • Differential regulation of myeloid leukemias by the bone marrow microenvironment 

      Krause, Daniela S.; Fulzele, Keertik; Catic, Andre; Sun, Chia Chi; Dombkowski, David; Hurley, Michael P.; Lezeau, Sanon; Attar, Eyal; Wu, Joy Y.; Lin, Herbert Y.; Divieti-Pajevic, Paola; Hasserjian, Robert P.; Schipani, Ernestina; Van Etten, Richard A.; Scadden, David T. (2013)
      Like their normal hematopoietic stem cell counterparts, leukemia stem cells (LSC) in chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) are presumed to reside in specific niches in the bone marrow ...

    • Differential regulation of symmetry genes and the evolution of floral morphologies 

      Hileman, L. C.; Kramer, Elena M.; Baum, D. A. (Proceedings of the National Academy of Sciences, 2003)
      Shifts in flower symmetry have occurred frequently during the diversification of angiosperms, and it is thought that such shifts play important roles in plant–pollinator interactions. In the model developmental system ...

    • Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain 

      Phelps, Christopher B.; Wang, Ruiqi R.; Choo, Shelly S.; Gaudet, Rachelle (American Society for Biochemistry and Molecular Biology, 2010)
      Transient receptor potential vanilloid (TRPV) channels, which include the thermosensitive TRPV1-V4, have large cytoplasmic regions flanking the transmembrane domain, including an N-terminal ankyrin repeat domain. We show ...

    • The differential representation of number and gender in Spanish 

      Fuchs, Zuzanna Z; Polinsky, Maria; Scontras, Gregory (Walter de Gruyter GmbH, 2015)
      This paper investigates the geometry of phi-features with a special emphasis on number and gender in Spanish. We address (i) whether number and gender evidence single- or multi-valued systems for their respective features, ...

    • Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2 

      Hoggatt, Jonathan; Mohammad, Khalid S.; Singh, Pratibha; Hoggatt, Amber F.; Chitteti, Brahmananda Reddy; Speth, Jennifer M.; Hu, Peirong; Poteat, Bradley A.; Stilger, Kayla N.; Ferraro, Francesca; Silberstein, Lev; Wong, Frankie K.; Farag, Sherif S.; Czader, Magdalena; Milne, Ginger L.; Breyer, Richard M.; Serezani, Carlos H.; Scadden, David T.; Guise, Theresa; Srour, Edward F.; Pelus, Louis M. (2013)
      SUMMARY To maintain lifelong production of blood cells, hematopoietic stem cells (HSC) are tightly regulated by inherent programs and extrinsic regulatory signals received from their microenvironmental niche. Long-term ...

    • Differentially Private Chi-Squared Hypothesis Testing: Goodness of Fit and Independence Testing 

      Gaboardi, Marco; Lim, Hyun-Woo; Rogers, Ryan M.; Vadhan, Salil P. (JMLR, 2016)
      Hypothesis testing is a useful statistical tool in determining whether a given model should be rejected based on a sample from the population. Sample data may contain sensitive information about individuals, such as medical ...

    • Differentially Private Release and Learning of Threshold Functions 

      Bun, Mark; Nissim, Kobbi; Stemmer, Uri; Vadhan, Salil P. (2015)
      We prove new upper and lower bounds on the sample complexity of (ε, δ) differentially private algorithms for releasing approximate answers to threshold functions. A threshold function cx over a totally ordered domain X ...

    • Differentiated Products Demand Systems from a Combination of Micro and Macro Data: The New Car Market 

      Berry, Steven; Levinsohn, James; Pakes, Ariel (University of Chicago Press, 2004)
      In this paper, we consider how rich sources of information on consumer choice can help to identify demand parameters in a widely used class of differentiated products demand models. Most important, we show how to use ...

    • Diffusion Monte Carlo Study of Para -Diiodobenzene Polymorphism Revisited 

      Hongo, Kenta; Watson, Mark A.; Iitaka, Toshiaki; Aspuru-Guzik, Alan; Maezono, Ryo (American Chemical Society (ACS), 2015)
      We revisit our investigation of the diffusion Monte Carlo (DMC) simulation of p-DIB molecular crystal polymorphism. [J. Phys. Chem. Lett. 2010, 1, 1789-1794] We perform, for the first time, a rigorous study of finite-size ...

    • Diffusion of Lithium in Bulk Amorphous Silicon: A Theoretical Study 

      Tritsaris, Georgios A.; Zhao, Kejie; Okeke, Onyekwelu U.; Kaxiras, Efthimios (American Chemical Society, 2012)

    • Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis 

      Edlow, Brian L.; Copen, William A.; Izzy, Saef; Bakhadirov, Khamid; van der Kouwe, Andre; Glenn, Mel B.; Greenberg, Steven M.; Greer, David M.; Wu, Ona (BioMed Central, 2016)
      Background: Diffusion tensor imaging (DTI) may have prognostic utility in patients with traumatic brain injury (TBI), but the optimal timing of DTI data acquisition is unknown because of dynamic changes in white matter ...

    • Diffusion theory of spin injection through resistive contacts 

      Rashba, Emmanuel (Springer Nature, 2002)
      Insertion of a resistive contact between a ferromagnetic metal and a semiconductor microstructure is of critical importance for achieving efficient spin injection into a semiconductor. However, the equations of the diffusion ...

    • Diffusion-controlled optical elements for optofluidics 

      Wolfe, Daniel B.; Vezenov, Dmitri V.; Mayers, Brian T.; Whitesides, George M.; Conroy, Richard S.; Prentiss, Mara G. (AIP Publishing, 2005)

    • Diffusive limit of lattice gas with mixing conditions 

      Varadhan, S. R. S.; Yau, Horng-Tzer (International Press of Boston, 1997)
      We prove, under certain mixing conditions, that the hydrodynamical limit of a stochastic lattice gas on the cubic lattice Z d is governed by a nonlinear diffusion equation. Following [VI], we characterize the diffusion ...

    • Digital Instability of a Confined Elastic Meniscus 

      Biggins, John S.; Saintyves, Baudouin; Wei, Zhiyan; Bouchaud, Elisabeth; Mahadevan, Lakshminarayanan (Proceedings of the National Academy of Sciences, 2013)
      Thin soft elastic layers serving as joints between relatively rigid bodies may function as sealants, thermal, electrical, or mechanical insulators, bearings, or adhesives. When such a joint is stressed, even though perfect ...

    • Digital phenotyping of suicidal thoughts 

      Kleiman, Evan M.; Turner, Brianna Joan; Fedor, Szymon; Beale, Eleanor E.; Picard, Rosalind W.; Huffman, Jeffery C.; Nock, Matthew K. (Wiley, 2018)
      Background: To examine whether there are subtypes of suicidal thinking using real-time digital monitoring, which allows for the measurement of such thoughts with greater temporal granularity than ever before possible. Methods: ...

    • Digital Publishing: A Home for Faculty in the Library -- Exercises in Innovation from Harvard Law School 

      DeMarco, Claire Amy; Courtney, Kyle K. (2018-02-22)
      As libraries continue transforming through the digital age, we are faced with a familiar opportunity for renewal: the deepening of the faculty-library relationship -- this time in a digital framework. Instead of simply ...

    • Digital Quantum Simulation of the Statistical Mechanics of a Frustrated Magnet 

      Zhang, Jingfu; Yung, Man-Hong; Laflamme, Raymond; Aspuru-Guzik, Alan; Baugh, Jonathan (Nature Publishing Group, 2012)
      Many problems of interest in physics, chemistry and computer science are equivalent to problems defined on systems of interacting spins. However, most such problems require computational resources that are out of reach ...

    • Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human 

      Zhang, Kun; Li, Jin Billy; Gao, Yuan; Egli, Dieter; Xie, Bin; Deng, Jie; Li, Zhe; Lee, Je-Hyuk; Aach, John Dennis; Leproust, Emily M; Eggan, Kevin Carl; Church, George McDonald (Nature Publishing Group, 2009)
      We developed a digital RNA allelotyping method for quantitatively interrogating allele-specific gene expression. This method involves ultra-deep sequencing of padlock captured SNPs from the transcriptome. We characterized ...

    • Digital RNA Sequencing Minimizes Sequence-Dependent Bias and Amplification Noise with Optimized Single-Molecule Barcodes 

      Shiroguchi, Katsuyuki; Jia, Tony Z; Sims, Peter A.; Xie, Xiaoliang Sunney (Proceedings of the National Academy of Sciences, 2012)
      RNA sequencing (RNA-Seq) is a powerful tool for transcriptome profiling, but is hampered by sequence-dependent bias and inaccuracy at low copy numbers intrinsic to exponential PCR amplification. We developed a simple ...