Browsing FAS Scholarly Articles by Keyword "Saccharomyces cerevisiae"
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The Cost of Gene Expression Underlies a Fitness Trade-Off in Yeast
(National Academy of Sciences, 2009)Natural selection optimizes an organism's genotype within the context of its environment. Adaptations to one environment can decrease fitness in another, revealing evolutionary trade-offs. Here, we show that the cost of ... -
The Fates of Mutant Lineages and the Distribution of Fitness Effects of Beneficial Mutations in Laboratory Budding Yeast Populations
(Genetics Society of America, 2014)The outcomes of evolution are determined by which mutations occur and fix. In rapidly adapting microbial populations, this process is particularly hard to predict because lineages with different beneficial mutations often ... -
Ranking Relations Using Analogies in Biological and Information Networks
(Institute of Mathematical Statistics, 2010)Analogical reasoning depends fundamentally on the ability to learn and generalize about relations between objects. We develop an approach to rela- tional learning which, given a set of pairs of objects S = {A[super](1) : ... -
Sucrose Utilization in Budding Yeast as a Model for the Origin of Undifferentiated Multicellularity
(Public Library of Science (PLoS), 2011)We use the budding yeast, Saccharomyces cerevisiae, to investigate one model for the initial emergence of multicellularity: the formation of multicellular aggregates as a result of incomplete cell separation. We combine ...