dc.contributor.author | Borra, Ronald JH | en_US |
dc.contributor.author | Cho, Hoon-Sung | en_US |
dc.contributor.author | Bowen, Spencer L | en_US |
dc.contributor.author | Attenberger, Ulrike | en_US |
dc.contributor.author | Arabasz, Grae | en_US |
dc.contributor.author | Catana, Ciprian | en_US |
dc.contributor.author | Josephson, Lee | en_US |
dc.contributor.author | Rosen, Bruce R | en_US |
dc.contributor.author | Guimaraes, Alexander R | en_US |
dc.contributor.author | Hooker, Jacob M | en_US |
dc.date.accessioned | 2015-09-01T13:27:58Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Borra, Ronald JH, Hoon-Sung Cho, Spencer L Bowen, Ulrike Attenberger, Grae Arabasz, Ciprian Catana, Lee Josephson, Bruce R Rosen, Alexander R Guimaraes, and Jacob M Hooker. 2015. “Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model.” EJNMMI Physics 2 (1): 6. doi:10.1186/s40658-015-0109-0. http://dx.doi.org/10.1186/s40658-015-0109-0. | en |
dc.identifier.issn | 2197-7364 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:21461993 | |
dc.description.abstract | Background: Simultaneous PET/MR imaging depends on MR-derived attenuation maps (mu-maps) for accurate attenuation correction of PET data. Currently, these maps are derived from gradient-echo-based MR sequences, which are sensitive to susceptibility changes. Iron oxide magnetic nanoparticles have been used in the measurement of blood volume, tumor microvasculature, tumor-associated macrophages, and characterizing lymph nodes. Our aim in this study was to assess whether the susceptibility effects associated with iron oxide nanoparticles can potentially affect measured 18F-FDG PET standardized uptake values (SUV) through effects on MR-derived attenuation maps. Methods: The study protocol was approved by the Institutional Animal Care and Use Committee. Using a Siemens Biograph mMR PET/MR scanner, we evaluated the effects of increasing concentrations of ferumoxytol and ferumoxytol aggregates on MR-derived mu-maps using an agarose phantom. In addition, we performed a baboon experiment evaluating the effects of a single i.v. ferumoxytol dose (10 mg/kg) on the liver, spleen, and pancreas 18F-FDG SUV at baseline (ferumoxytol-naïve), within the first hour and at 1, 3, 5, and 11 weeks. Results: Phantom experiments showed mu-map artifacts starting at ferumoxytol aggregate concentrations of 10 to 20 mg/kg. The in vivo baboon data demonstrated a 53% decrease of observed 18F-FDG SUV compared to baseline within the first hour in the liver, persisting at least 11 weeks. Conclusions: A single ferumoxytol dose can affect measured SUV for at least 3 months, which should be taken into account when administrating ferumoxytol in patients needing sequential PET/MR scans. Advances in knowledge 1. Ferumoxytol aggregates, but not ferumoxytol alone, produce significant artifacts in MR-derived attenuation correction maps at approximate clinical dose levels of 10 mg/kg. 2. When performing simultaneous whole-body 18F-FDG PET/MR, a single dose of ferumoxytol can result in observed SUV decreases up to 53%, depending on the amount of ferumoxytol aggregates in the studied tissue. Implications for patient care Administration of a single, clinically relevant, dose of ferumoxytol can potentially result in changes in observed SUV for a prolonged period of time in the setting of simultaneous PET/MR. These potential changes should be considered in particular when administering ferumoxytol to patients with expected future PET/MR studies, as ferumoxytol-induced SUV changes might interfere with therapy assessment. Electronic supplementary material The online version of this article (doi:10.1186/s40658-015-0109-0) contains supplementary material, which is available to authorized users. | en |
dc.language.iso | en_US | en |
dc.publisher | Springer International Publishing | en |
dc.relation.isversionof | doi:10.1186/s40658-015-0109-0 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544618/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | PET | en |
dc.subject | MRI | en |
dc.subject | PET/MR | en |
dc.subject | Multimodal imaging | en |
dc.subject | Ferumoxytol | en |
dc.subject | Attenuation correction | en |
dc.title | Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | EJNMMI Physics | en |
dash.depositing.author | Catana, Ciprian | en_US |
dc.date.available | 2015-09-01T13:27:58Z | |
dc.identifier.doi | 10.1186/s40658-015-0109-0 | * |
dash.contributor.affiliated | Catana, Ciprian | |
dash.contributor.affiliated | Josephson, Lee | |
dash.contributor.affiliated | Hooker, Jacob | |
dash.contributor.affiliated | Rosen, Bruce | |